Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient

Chronic Q fever caused by Coxiella burnetii is uncommon in the United States and is most often associated with infective endocarditis. We present a 52-year-old woman with a history of aortic valve replacement and rheumatoid arthritis treated with Etanercept with chronic Q fever manifesting as prosth...

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Main Authors: Shailee Y. Shah, Christopher Kovacs, Carmela D. Tan, Gosta Pettersson, Nabin K. Shrestha, Larry Lutwick, Steven M. Gordon
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:IDCases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214250915000244
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author Shailee Y. Shah
Christopher Kovacs
Carmela D. Tan
Gosta Pettersson
Nabin K. Shrestha
Larry Lutwick
Steven M. Gordon
author_facet Shailee Y. Shah
Christopher Kovacs
Carmela D. Tan
Gosta Pettersson
Nabin K. Shrestha
Larry Lutwick
Steven M. Gordon
author_sort Shailee Y. Shah
collection DOAJ
description Chronic Q fever caused by Coxiella burnetii is uncommon in the United States and is most often associated with infective endocarditis. We present a 52-year-old woman with a history of aortic valve replacement and rheumatoid arthritis treated with Etanercept with chronic Q fever manifesting as prosthetic valve infective endocarditis. Explanted valve tissue showed organisms confirmed to be C. burnetii by PCR (polymerase chain reaction) sequencing. She subsequently reported consumption of unpasteurized cow milk which was the likely source of C. burnetii. She continues to do well 6 months after valve replacement on oral doxycycline and hydroxychloroquine.
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spelling doaj.art-189f7fa95cfd45018ff78b59edb3e5922022-12-21T19:20:28ZengElsevierIDCases2214-25092015-01-0124949610.1016/j.idcr.2015.09.002Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patientShailee Y. Shah0Christopher Kovacs1Carmela D. Tan2Gosta Pettersson3Nabin K. Shrestha4Larry Lutwick5Steven M. Gordon6Department of Infectious Diseases, Cleveland Clinic, OH, United StatesDepartment of Infectious Diseases, Cleveland Clinic, OH, United StatesDepartment of Pathology, Cleveland Clinic, OH, United StatesDepartment of Cardiovascular Surgery, Cleveland Clinic, OH, United StatesDepartment of Infectious Diseases, Cleveland Clinic, OH, United StatesDepartment of Infectious Diseases, Western Michigan University, Kalamazoo, MI, United StatesDepartment of Infectious Diseases, Cleveland Clinic, OH, United StatesChronic Q fever caused by Coxiella burnetii is uncommon in the United States and is most often associated with infective endocarditis. We present a 52-year-old woman with a history of aortic valve replacement and rheumatoid arthritis treated with Etanercept with chronic Q fever manifesting as prosthetic valve infective endocarditis. Explanted valve tissue showed organisms confirmed to be C. burnetii by PCR (polymerase chain reaction) sequencing. She subsequently reported consumption of unpasteurized cow milk which was the likely source of C. burnetii. She continues to do well 6 months after valve replacement on oral doxycycline and hydroxychloroquine.http://www.sciencedirect.com/science/article/pii/S2214250915000244Coxiella burnetii endocarditisQ fever endocarditisEndocarditis and EtanerceptUnpasteurized milk infection
spellingShingle Shailee Y. Shah
Christopher Kovacs
Carmela D. Tan
Gosta Pettersson
Nabin K. Shrestha
Larry Lutwick
Steven M. Gordon
Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient
IDCases
Coxiella burnetii endocarditis
Q fever endocarditis
Endocarditis and Etanercept
Unpasteurized milk infection
title Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient
title_full Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient
title_fullStr Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient
title_full_unstemmed Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient
title_short Delayed diagnosis of Q fever endocarditis in a rheumatoid arthritis patient
title_sort delayed diagnosis of q fever endocarditis in a rheumatoid arthritis patient
topic Coxiella burnetii endocarditis
Q fever endocarditis
Endocarditis and Etanercept
Unpasteurized milk infection
url http://www.sciencedirect.com/science/article/pii/S2214250915000244
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