FOXC1 Downregulates Nanog Expression by Recruiting HDAC2 to Its Promoter in F9 Cells Treated by Retinoic Acid

FOXC1 Downregulates Nanog Expression by Recruiting HDAC2 to Its Promoter in F9 Cells Treated by Retinoic Acid

FOXC1, a transcription factor involved in cell differentiation and embryogenesis, is demonstrated to be a negative regulator of Nanog in this study. FOXC1 is up-regulated in retinoic acid-induced differentiation of F9 Embryonal Carcinoma (EC) cells; furthermore, FOXC1 specifically inhibits the core...

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Bibliographic Details
Main Authors: Hongni Xue, Fayang Liu, Zhiying Ai, Jie Ke, Mengying Yu, Bingxue Chen, Zekun Guo
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
F9 cells
ARTA
Nanog
promoter analysis
FOXC1 interactome
HDAC2
Online Access:https://www.mdpi.com/1422-0067/22/5/2255

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