Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men
PURPOSE Leukocyte telomere length (LTL) is a potential indicator of cellular senescence. However, its relationship with the type and volume of regular exercise is unclear. Therefore, we investigated the effects of the type and volume of long-term regular exercise on the LTL in middle-aged men (N=109...
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| Format: | Article |
| Language: | Korean |
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The Korean Society of Exercise Physiology
2021-11-01
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| Series: | 운동과학 |
| Subjects: | |
| Online Access: | http://www.ksep-es.org/upload/pdf/ksep-2021-00437.pdf |
| _version_ | 1798025411680010240 |
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| author | Yun-A Shin Chang-Sun Kim Sang-Hyun Lee Yong-Woo Lee Jun-Soo Kim Dong-Ho Park |
| author_facet | Yun-A Shin Chang-Sun Kim Sang-Hyun Lee Yong-Woo Lee Jun-Soo Kim Dong-Ho Park |
| author_sort | Yun-A Shin |
| collection | DOAJ |
| description | PURPOSE Leukocyte telomere length (LTL) is a potential indicator of cellular senescence. However, its relationship with the type and volume of regular exercise is unclear. Therefore, we investigated the effects of the type and volume of long-term regular exercise on the LTL in middle-aged men (N=109, mean age=44.7±4.1 years [range: 40-56 years]). METHODS For all participants, the volume of physical activity (PA) was evaluated using a self-report questionnaire, and blood samples were collected simultaneously. We cross-sectionally examined the associations among the type and volume of PA, LTL, telomerase activity (TA), mitochondrial DNA copy number (mtDNA), and body composition in three groups: 1) bodybuilders (BBs) with at least 5 years of athletic experience (n=36, mean age: 42.3±3.3 years [40-51 years]), 2) cyclists (CCs) with an athletic career similar to that of the BBs (n=37, mean age: 45.4±4.4 years [range: 40-53 years]), and 3) healthy ordinary people (CON; n=36, mean age: 46.3±3.3 years [range: 40-56 years]). RESULTS The LTL showed a significant positive correlation with the volume of PA (r=.285, p=.003), regardless of the type of PA. Furthermore, the LTLs were longer in the BB (p=.007) and CC (p=.003) groups (who performed moderate-to-vigorous PA for 150 minutes or more per week) than in the CON group. Conversely, the TA was significantly higher in the BB group (p=.009) than in the CON group; however, it only tended to be high in the CC group (p=.115). There were no intergroup differences in both the mtDNA (p=.127) and 8-hydroxydeoxyguanosine (p=.289) levels. CONCLUSIONS The TA was found to increase, and thus prevent telomere loss, in middle-aged men who performed PA of moderateto-vigorous intensity, regardless of the PA type. |
| first_indexed | 2024-04-11T18:18:30Z |
| format | Article |
| id | doaj.art-18a20ee7fa274564b791f223129c702f |
| institution | Directory Open Access Journal |
| issn | 1226-1726 2384-0544 |
| language | Korean |
| last_indexed | 2024-04-11T18:18:30Z |
| publishDate | 2021-11-01 |
| publisher | The Korean Society of Exercise Physiology |
| record_format | Article |
| series | 운동과학 |
| spelling | doaj.art-18a20ee7fa274564b791f223129c702f2022-12-22T04:09:49ZkorThe Korean Society of Exercise Physiology운동과학1226-17262384-05442021-11-0130446247110.15857/ksep.2021.00437937Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged MenYun-A Shin0Chang-Sun Kim1Sang-Hyun Lee2Yong-Woo Lee3Jun-Soo Kim4Dong-Ho Park5Department of Prescription & Rehabilitation of Exercise, College of Sports Science, Dankook University, Cheonan, KoreaDepartment of Physical Education, Dongduck Women’s University, Seoul, KoreaDepartment of Kinesiology, Inha University, Incheon, KoreaDepartment of Physical Education, Korea National Sport University, Seoul, KoreaDepartment of Sports Outdoors, Eulji University, Seongnam, KoreaDepartment of Kinesiology, Inha University, Incheon, KoreaPURPOSE Leukocyte telomere length (LTL) is a potential indicator of cellular senescence. However, its relationship with the type and volume of regular exercise is unclear. Therefore, we investigated the effects of the type and volume of long-term regular exercise on the LTL in middle-aged men (N=109, mean age=44.7±4.1 years [range: 40-56 years]). METHODS For all participants, the volume of physical activity (PA) was evaluated using a self-report questionnaire, and blood samples were collected simultaneously. We cross-sectionally examined the associations among the type and volume of PA, LTL, telomerase activity (TA), mitochondrial DNA copy number (mtDNA), and body composition in three groups: 1) bodybuilders (BBs) with at least 5 years of athletic experience (n=36, mean age: 42.3±3.3 years [40-51 years]), 2) cyclists (CCs) with an athletic career similar to that of the BBs (n=37, mean age: 45.4±4.4 years [range: 40-53 years]), and 3) healthy ordinary people (CON; n=36, mean age: 46.3±3.3 years [range: 40-56 years]). RESULTS The LTL showed a significant positive correlation with the volume of PA (r=.285, p=.003), regardless of the type of PA. Furthermore, the LTLs were longer in the BB (p=.007) and CC (p=.003) groups (who performed moderate-to-vigorous PA for 150 minutes or more per week) than in the CON group. Conversely, the TA was significantly higher in the BB group (p=.009) than in the CON group; however, it only tended to be high in the CC group (p=.115). There were no intergroup differences in both the mtDNA (p=.127) and 8-hydroxydeoxyguanosine (p=.289) levels. CONCLUSIONS The TA was found to increase, and thus prevent telomere loss, in middle-aged men who performed PA of moderateto-vigorous intensity, regardless of the PA type.http://www.ksep-es.org/upload/pdf/ksep-2021-00437.pdfmiddle-aged mentelomere lengthtype of physical activitytelomerasemtdna copy number |
| spellingShingle | Yun-A Shin Chang-Sun Kim Sang-Hyun Lee Yong-Woo Lee Jun-Soo Kim Dong-Ho Park Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men 운동과학 middle-aged men telomere length type of physical activity telomerase mtdna copy number |
| title | Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men |
| title_full | Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men |
| title_fullStr | Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men |
| title_full_unstemmed | Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men |
| title_short | Effects of the Type and Volume of Physical Activity on Leukocyte Telomere Length in Middle-Aged Men |
| title_sort | effects of the type and volume of physical activity on leukocyte telomere length in middle aged men |
| topic | middle-aged men telomere length type of physical activity telomerase mtdna copy number |
| url | http://www.ksep-es.org/upload/pdf/ksep-2021-00437.pdf |
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