Brevibacterium paucivorans bacteremia: case report and review of the literature
Abstract Background Brevibacteria are obligate aerobic gram-positive rods that are associated with milk products and are also found on human skin. Brevibacterium has been reported as a rare cause of catheter related blood steam infection mainly in immunocompromised hosts such as malignancies or AIDS...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-019-3962-y |
| _version_ | 1818291668413054976 |
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| author | Nobuhiro Asai Hiroyuki Suematsu Atsuko Yamada Hiroki Watanabe Naoya Nishiyama Daisuke Sakanashi Hideo Kato Arufumi Shiota Mao Hagihara Yusuke Koizumi Yuka Yamagishi Hiroshige Mikamo |
| author_facet | Nobuhiro Asai Hiroyuki Suematsu Atsuko Yamada Hiroki Watanabe Naoya Nishiyama Daisuke Sakanashi Hideo Kato Arufumi Shiota Mao Hagihara Yusuke Koizumi Yuka Yamagishi Hiroshige Mikamo |
| author_sort | Nobuhiro Asai |
| collection | DOAJ |
| description | Abstract Background Brevibacteria are obligate aerobic gram-positive rods that are associated with milk products and are also found on human skin. Brevibacterium has been reported as a rare cause of catheter related blood steam infection mainly in immunocompromised hosts such as malignancies or AIDS patients. Case presentation A 94-year old woman, which had a past history of diabetes mellitus and chronic heart failure, presented with high fever associated with decreased oral intake and appetite loss and was admitted to our institute. A physical examination at the time of presentation was unremarkable. On day 2, both blood cultures collected on admission became positive with coryneform organism within 24 h without Staphylococci and Brevibacterium species were identified by Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Subsequently, genetic investigation by 16S ribosomal RNA analysis was performed in order to identify the organism. Finally, the result identified this pathogen as Brevibacterium paucivorans with 99.5% homology on the Ez taxon database. The patient was started empirically on meropenem and teicoplanin for broad-spectrum antibiotic coverage. The patient’s fever finally abated and labs were also improved. On day 14, the antibiotic therapy was discontinued. The site of infections was unknown. We hereby report a case of Brevibacterium paicivorans bacteremia in an immunocompetent patient and review cases of Brevibacterium specises bacteremia previously reported. This is the first case of B. paucivorans bacteremia as far as we could search. Conclusion Physicians and microbiologists should be aware that Brevibacteria are uncommon but important agents which could cause opportunistic infections in immunocompetent. |
| first_indexed | 2024-12-13T02:47:43Z |
| format | Article |
| id | doaj.art-18a32cea2a1b491f810c2af870b018a4 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T02:47:43Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-18a32cea2a1b491f810c2af870b018a42022-12-22T00:02:08ZengBMCBMC Infectious Diseases1471-23342019-04-011911510.1186/s12879-019-3962-yBrevibacterium paucivorans bacteremia: case report and review of the literatureNobuhiro Asai0Hiroyuki Suematsu1Atsuko Yamada2Hiroki Watanabe3Naoya Nishiyama4Daisuke Sakanashi5Hideo Kato6Arufumi Shiota7Mao Hagihara8Yusuke Koizumi9Yuka Yamagishi10Hiroshige Mikamo11Department of Clinical Infectious Diseases, Aichi Medical University HospitalDepartment of Infection Control and Prevention, Aichi Medical University HospitalDepartment of Infection Control and Prevention, Aichi Medical University HospitalDepartment of Clinical Infectious Diseases, Aichi Medical University HospitalDepartment of Clinical Infectious Diseases, Aichi Medical University HospitalDepartment of Infection Control and Prevention, Aichi Medical University HospitalDepartment of Infection Control and Prevention, Aichi Medical University HospitalDepartment of Infection Control and Prevention, Aichi Medical University HospitalDepartment of Infection Control and Prevention, Aichi Medical University HospitalDepartment of Clinical Infectious Diseases, Aichi Medical University HospitalDepartment of Clinical Infectious Diseases, Aichi Medical University HospitalDepartment of Clinical Infectious Diseases, Aichi Medical University HospitalAbstract Background Brevibacteria are obligate aerobic gram-positive rods that are associated with milk products and are also found on human skin. Brevibacterium has been reported as a rare cause of catheter related blood steam infection mainly in immunocompromised hosts such as malignancies or AIDS patients. Case presentation A 94-year old woman, which had a past history of diabetes mellitus and chronic heart failure, presented with high fever associated with decreased oral intake and appetite loss and was admitted to our institute. A physical examination at the time of presentation was unremarkable. On day 2, both blood cultures collected on admission became positive with coryneform organism within 24 h without Staphylococci and Brevibacterium species were identified by Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Subsequently, genetic investigation by 16S ribosomal RNA analysis was performed in order to identify the organism. Finally, the result identified this pathogen as Brevibacterium paucivorans with 99.5% homology on the Ez taxon database. The patient was started empirically on meropenem and teicoplanin for broad-spectrum antibiotic coverage. The patient’s fever finally abated and labs were also improved. On day 14, the antibiotic therapy was discontinued. The site of infections was unknown. We hereby report a case of Brevibacterium paicivorans bacteremia in an immunocompetent patient and review cases of Brevibacterium specises bacteremia previously reported. This is the first case of B. paucivorans bacteremia as far as we could search. Conclusion Physicians and microbiologists should be aware that Brevibacteria are uncommon but important agents which could cause opportunistic infections in immunocompetent.http://link.springer.com/article/10.1186/s12879-019-3962-yBrevibacterium paucivoransCompromised hostBacteremiaImmunocompetent |
| spellingShingle | Nobuhiro Asai Hiroyuki Suematsu Atsuko Yamada Hiroki Watanabe Naoya Nishiyama Daisuke Sakanashi Hideo Kato Arufumi Shiota Mao Hagihara Yusuke Koizumi Yuka Yamagishi Hiroshige Mikamo Brevibacterium paucivorans bacteremia: case report and review of the literature BMC Infectious Diseases Brevibacterium paucivorans Compromised host Bacteremia Immunocompetent |
| title | Brevibacterium paucivorans bacteremia: case report and review of the literature |
| title_full | Brevibacterium paucivorans bacteremia: case report and review of the literature |
| title_fullStr | Brevibacterium paucivorans bacteremia: case report and review of the literature |
| title_full_unstemmed | Brevibacterium paucivorans bacteremia: case report and review of the literature |
| title_short | Brevibacterium paucivorans bacteremia: case report and review of the literature |
| title_sort | brevibacterium paucivorans bacteremia case report and review of the literature |
| topic | Brevibacterium paucivorans Compromised host Bacteremia Immunocompetent |
| url | http://link.springer.com/article/10.1186/s12879-019-3962-y |
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