Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel Disease
Background: Endoscopic evaluation is the gold standard for monitoring the disease activity in inflammatory bowel disease (IBD) but the procedure is invasive and not appropriate for frequent use, especially in the paediatric population. The aim of the present study was to assess the correlation betwe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2020-06-01
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| Series: | Folia Medica |
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| Online Access: | https://foliamedica.bg/article/47830/download/pdf/ |
| _version_ | 1818379946731503616 |
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| author | Rayna Shentova Mila Baycheva Denitza Kofinova Petio Hadjiiski Penka Yaneva |
| author_facet | Rayna Shentova Mila Baycheva Denitza Kofinova Petio Hadjiiski Penka Yaneva |
| author_sort | Rayna Shentova |
| collection | DOAJ |
| description | Background: Endoscopic evaluation is the gold standard for monitoring the disease activity in inflammatory bowel disease (IBD) but the procedure is invasive and not appropriate for frequent use, especially in the paediatric population. The aim of the present study was to assess the correlation between the levels of several inflammatory biomarkers and the degree of intestinal inflammation in paediatric patients with IBD.Materials and methods: A single center study including 31 children with ulcerative colitis (UC) and 22 children with Crohn’s disease (CD) with different disease duration and activity. All participants provided blood samples to measure the levels of white blood cell count, platelets, C-reactive protein, erythrocyte sedimentation rate, albumin and fibrinogen, and faecal samples for measurement of faecal calprotectin and faecal alpha-1 antitrypsin. All participants underwent endoscopic evaluation. Endoscopic disease activity was assessed according to the Mayo Endoscopic Subscore and Simple Endoscopic Score for Crohn‘s Disease in UC and CD patients, respectively.Results: 135 visits were included: 73 for UC patients and 62 for CD patients. In UC patients the strongest correlation was between the Mayo Endoscopic Subscore and the faecal calprotectin (r=0.867, p<0.001) followed by the albumin (r=0.523, p<0.001) and the C-reactive protein (r=0.487, p<0.001). In CD the strongest correlation was between the Simple Endoscopic Score for Crohn’s disease and the faecal calprotectin (r=0.872, p<0.001) followed by the C-reactive protein (0.708, p<0.001) and the erythrocyte sedimentation rate (0.605, p<0.001).Conclusions: The faecal calprotectin is a valuable surrogate marker of intestinal inflammation that is useful for monitoring of a disease activity in paediatric patients with IBD. |
| first_indexed | 2024-12-14T02:10:52Z |
| format | Article |
| id | doaj.art-18a567a932e241708b1a6666ab8cbb8c |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-12-14T02:10:52Z |
| publishDate | 2020-06-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-18a567a932e241708b1a6666ab8cbb8c2022-12-21T23:20:45ZengPensoft PublishersFolia Medica1314-21432020-06-0162227127510.3897/folmed.62.e4783047830Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel DiseaseRayna Shentova0Mila Baycheva1Denitza Kofinova2Petio Hadjiiski3Penka Yaneva4Department of Gastroenterology and Hepatology, Prof. Ivan Mitev University Pediatric Hospital, Medical University of SofiaDepartment of Gastroenterology and Hepatology, Prof. Ivan Mitev University Pediatric Hospital, Medical University of SofiaDepartment of Gastroenterology and Hepatology, Prof. Ivan Mitev University Pediatric Hospital, Medical University of SofiaDepartment of Gastroenterology and Hepatology, Prof. Ivan Mitev University Pediatric Hospital, Medical University of SofiaDepartment of Gastroenterology and Hepatology, Prof. Ivan Mitev University Pediatric Hospital, Medical University of SofiaBackground: Endoscopic evaluation is the gold standard for monitoring the disease activity in inflammatory bowel disease (IBD) but the procedure is invasive and not appropriate for frequent use, especially in the paediatric population. The aim of the present study was to assess the correlation between the levels of several inflammatory biomarkers and the degree of intestinal inflammation in paediatric patients with IBD.Materials and methods: A single center study including 31 children with ulcerative colitis (UC) and 22 children with Crohn’s disease (CD) with different disease duration and activity. All participants provided blood samples to measure the levels of white blood cell count, platelets, C-reactive protein, erythrocyte sedimentation rate, albumin and fibrinogen, and faecal samples for measurement of faecal calprotectin and faecal alpha-1 antitrypsin. All participants underwent endoscopic evaluation. Endoscopic disease activity was assessed according to the Mayo Endoscopic Subscore and Simple Endoscopic Score for Crohn‘s Disease in UC and CD patients, respectively.Results: 135 visits were included: 73 for UC patients and 62 for CD patients. In UC patients the strongest correlation was between the Mayo Endoscopic Subscore and the faecal calprotectin (r=0.867, p<0.001) followed by the albumin (r=0.523, p<0.001) and the C-reactive protein (r=0.487, p<0.001). In CD the strongest correlation was between the Simple Endoscopic Score for Crohn’s disease and the faecal calprotectin (r=0.872, p<0.001) followed by the C-reactive protein (0.708, p<0.001) and the erythrocyte sedimentation rate (0.605, p<0.001).Conclusions: The faecal calprotectin is a valuable surrogate marker of intestinal inflammation that is useful for monitoring of a disease activity in paediatric patients with IBD.https://foliamedica.bg/article/47830/download/pdf/faecal calprotectinsurrogate markerspaediatric |
| spellingShingle | Rayna Shentova Mila Baycheva Denitza Kofinova Petio Hadjiiski Penka Yaneva Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel Disease Folia Medica faecal calprotectin surrogate markers paediatric |
| title | Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel Disease |
| title_full | Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel Disease |
| title_fullStr | Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel Disease |
| title_short | Surrogate Markers of Intestinal Inflammation in Paediatric Patients with Inflammatory Bowel Disease |
| title_sort | surrogate markers of intestinal inflammation in paediatric patients with inflammatory bowel disease |
| topic | faecal calprotectin surrogate markers paediatric |
| url | https://foliamedica.bg/article/47830/download/pdf/ |
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