COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells

COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells

Abstract Aims Investigate the effect and mechanism of COX-2 on viability, intestinal metaplasia, and atypia in human esophageal squamous and Barrett esophageal cell lines. Methods Human esophageal squamous and Barrett esophageal cell lines were transfected with a COX-2 expression vector and a COX-2...

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Bibliographic Details
Main Authors: Shen Jiangang, Kang Nayoung, Wang Hongfang, Li Junda, Chen Li, Bai Xuefeng, Li Mingsong
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Molecular and Cell Biology
Subjects:
Barrett’s esophagus
Esophageal adenocarcinoma
Cyclooxygenase-2
Nuclear factor kappa B
Caudal-related homeobox transcription factor-2
Bone morphogenic protein-4
Online Access:https://doi.org/10.1186/s12860-022-00418-5

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