Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.

Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.

C(2) domains are well characterized as Ca(2+)/phospholipid-binding modules, but little is known about how they mediate protein-protein interactions. In neurons, a Munc13-1 C(2)A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show tha...

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Bibliographic Details
Main Authors: Jun Lu, Mischa Machius, Irina Dulubova, Han Dai, Thomas C Südhof, Diana R Tomchick, Josep Rizo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1472246?pdf=render

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