The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus
Age related hearing loss (presbycusis) is a natural process represented by elevated auditory thresholds and decreased speech intelligibility, especially in noisy conditions. Tinnitus is a phantom sound that also potentially leads to cortical changes, with its highest occurrence coinciding with the c...
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| Format: | Article |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2020.553461/full |
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| author | Oliver Profant Oliver Profant Antonín Škoch Jaroslav Tintěra Veronika Svobodová Veronika Svobodová Diana Kuchárová Diana Kuchárová Jana Svobodová Burianová Josef Syka |
| author_facet | Oliver Profant Oliver Profant Antonín Škoch Jaroslav Tintěra Veronika Svobodová Veronika Svobodová Diana Kuchárová Diana Kuchárová Jana Svobodová Burianová Josef Syka |
| author_sort | Oliver Profant |
| collection | DOAJ |
| description | Age related hearing loss (presbycusis) is a natural process represented by elevated auditory thresholds and decreased speech intelligibility, especially in noisy conditions. Tinnitus is a phantom sound that also potentially leads to cortical changes, with its highest occurrence coinciding with the clinical onset of presbycusis. The aim of our project was to identify age, hearing loss and tinnitus related structural changes, within the auditory system and associated structures. Groups of subjects with presbycusis and tinnitus (22 subjects), with only presbycusis (24 subjects), young tinnitus patients with normal hearing (10 subjects) and young controls (17 subjects), underwent an audiological examination to characterize hearing loss and tinnitus. In addition, MRI (3T MR system, analysis in Freesurfer software) scans were used to identify changes in the cortical and subcortical structures. The following areas of the brain were analyzed: Heschl gyrus (HG), planum temporale (PT), primary visual cortex (V1), gyrus parahippocampus (PH), anterior insula (Ins), amygdala (Amg), and hippocampus (HP). A statistical analysis was performed in R framework using linear mixed-effects models with explanatory variables: age, tinnitus, laterality and hearing. In all of the cortical structures, the gray matter thickness decreased significantly with aging without having an effect on laterality (differences between the left and right hemispheres). The decrease in the gray matter thickness was faster in the HG, PT and Ins in comparison with the PH and V1. Aging did not influence the surface of the cortical areas, however there were differences between the surface size of the reported regions in the left and right hemispheres. Hearing loss caused only a borderline decrease of the cortical surface in the HG. Tinnitus was accompanied by a borderline decrease of the Ins surface and led to an increase in the volume of Amy and HP. In summary, aging is accompanied by a decrease in the cortical gray matter thickness; hearing loss only has a limited effect on the structure of the investigated cortical areas and tinnitus causes structural changes which are predominantly within the limbic system and insula, with the structure of the auditory system only being minimally affected. |
| first_indexed | 2024-12-20T01:07:20Z |
| format | Article |
| id | doaj.art-18a76a4a415c431aa9289c8e9b8a743f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-20T01:07:20Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-18a76a4a415c431aa9289c8e9b8a743f2022-12-21T19:58:47ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-12-011210.3389/fnagi.2020.553461553461The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and HippocampusOliver Profant0Oliver Profant1Antonín Škoch2Jaroslav Tintěra3Veronika Svobodová4Veronika Svobodová5Diana Kuchárová6Diana Kuchárová7Jana Svobodová Burianová8Josef Syka9Department of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaDepartment of Otorhinolaryngology, 3rd Faculty of Medicine, Faculty Hospital Kralovske Vinohrady, Charles University, Prague, CzechiaMR Unit, Institute of Clinical and Experimental Medicine, Prague, CzechiaMR Unit, Institute of Clinical and Experimental Medicine, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaDepartment of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Charles University, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaDepartment of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Charles University, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, CzechiaAge related hearing loss (presbycusis) is a natural process represented by elevated auditory thresholds and decreased speech intelligibility, especially in noisy conditions. Tinnitus is a phantom sound that also potentially leads to cortical changes, with its highest occurrence coinciding with the clinical onset of presbycusis. The aim of our project was to identify age, hearing loss and tinnitus related structural changes, within the auditory system and associated structures. Groups of subjects with presbycusis and tinnitus (22 subjects), with only presbycusis (24 subjects), young tinnitus patients with normal hearing (10 subjects) and young controls (17 subjects), underwent an audiological examination to characterize hearing loss and tinnitus. In addition, MRI (3T MR system, analysis in Freesurfer software) scans were used to identify changes in the cortical and subcortical structures. The following areas of the brain were analyzed: Heschl gyrus (HG), planum temporale (PT), primary visual cortex (V1), gyrus parahippocampus (PH), anterior insula (Ins), amygdala (Amg), and hippocampus (HP). A statistical analysis was performed in R framework using linear mixed-effects models with explanatory variables: age, tinnitus, laterality and hearing. In all of the cortical structures, the gray matter thickness decreased significantly with aging without having an effect on laterality (differences between the left and right hemispheres). The decrease in the gray matter thickness was faster in the HG, PT and Ins in comparison with the PH and V1. Aging did not influence the surface of the cortical areas, however there were differences between the surface size of the reported regions in the left and right hemispheres. Hearing loss caused only a borderline decrease of the cortical surface in the HG. Tinnitus was accompanied by a borderline decrease of the Ins surface and led to an increase in the volume of Amy and HP. In summary, aging is accompanied by a decrease in the cortical gray matter thickness; hearing loss only has a limited effect on the structure of the investigated cortical areas and tinnitus causes structural changes which are predominantly within the limbic system and insula, with the structure of the auditory system only being minimally affected.https://www.frontiersin.org/articles/10.3389/fnagi.2020.553461/fullpresbycusistinnitusauditory systemlimbic systemmorphometry |
| spellingShingle | Oliver Profant Oliver Profant Antonín Škoch Jaroslav Tintěra Veronika Svobodová Veronika Svobodová Diana Kuchárová Diana Kuchárová Jana Svobodová Burianová Josef Syka The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus Frontiers in Aging Neuroscience presbycusis tinnitus auditory system limbic system morphometry |
| title | The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus |
| title_full | The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus |
| title_fullStr | The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus |
| title_full_unstemmed | The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus |
| title_short | The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus |
| title_sort | influence of aging hearing and tinnitus on the morphology of cortical gray matter amygdala and hippocampus |
| topic | presbycusis tinnitus auditory system limbic system morphometry |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2020.553461/full |
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