Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells
Objective. Single-walled carbon nanotubes (SWCNTs) are considered to be one of the nanomaterials attractive for biomedical applications, particularly in the health sciences as imaging probes and drug carriers, especially in the field of cancer therapy. The increasing exploitation of nanotubes necess...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-01-01
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| Series: | Endocrine Regulations |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/enr-2023-0020 |
| _version_ | 1797375915471142912 |
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| author | Minchenko Dmytro O. Rudnytska Olha V. Khita Olena O. Kulish Yuliia V. Viletska Yuliia M. Halkin Oleh V. Danilovskyi Serhiy V. Ratushna Oksana O. Minchenko Oleksandr H. |
| author_facet | Minchenko Dmytro O. Rudnytska Olha V. Khita Olena O. Kulish Yuliia V. Viletska Yuliia M. Halkin Oleh V. Danilovskyi Serhiy V. Ratushna Oksana O. Minchenko Oleksandr H. |
| author_sort | Minchenko Dmytro O. |
| collection | DOAJ |
| description | Objective. Single-walled carbon nanotubes (SWCNTs) are considered to be one of the nanomaterials attractive for biomedical applications, particularly in the health sciences as imaging probes and drug carriers, especially in the field of cancer therapy. The increasing exploitation of nanotubes necessitates a comprehensive evaluation of the potential impact of these nanomaterials, which purposefully accumulate in the cell nucleus, on the human health and the function of the genome in the normal and tumor tissues. The aim of this study was to investigate the sensitivity of the expression of DNAJB9 and some other genes associated with the endoplasmic reticulum (ER) stress and cell proliferation to low doses of SWCNTs in normal human astrocytes (NHA/TS) and glioblastoma cells (U87MG) with and without an inhibition of ERN1 signaling pathway of the ER stress. |
| first_indexed | 2024-03-08T19:31:09Z |
| format | Article |
| id | doaj.art-18a811d499954a08a86a5931c08b6421 |
| institution | Directory Open Access Journal |
| issn | 1336-0329 |
| language | English |
| last_indexed | 2024-03-08T19:31:09Z |
| publishDate | 2023-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj.art-18a811d499954a08a86a5931c08b64212023-12-26T07:42:09ZengSciendoEndocrine Regulations1336-03292023-01-0157116217210.2478/enr-2023-0020Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cellsMinchenko Dmytro O.0Rudnytska Olha V.1Khita Olena O.2Kulish Yuliia V.3Viletska Yuliia M.4Halkin Oleh V.5Danilovskyi Serhiy V.6Ratushna Oksana O.7Minchenko Oleksandr H.81Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, UkraineObjective. Single-walled carbon nanotubes (SWCNTs) are considered to be one of the nanomaterials attractive for biomedical applications, particularly in the health sciences as imaging probes and drug carriers, especially in the field of cancer therapy. The increasing exploitation of nanotubes necessitates a comprehensive evaluation of the potential impact of these nanomaterials, which purposefully accumulate in the cell nucleus, on the human health and the function of the genome in the normal and tumor tissues. The aim of this study was to investigate the sensitivity of the expression of DNAJB9 and some other genes associated with the endoplasmic reticulum (ER) stress and cell proliferation to low doses of SWCNTs in normal human astrocytes (NHA/TS) and glioblastoma cells (U87MG) with and without an inhibition of ERN1 signaling pathway of the ER stress.https://doi.org/10.2478/enr-2023-0020swcntsdnajb9brca1ddx58mrna expressionern1normal human astrocytesu87 glioblastoma cells |
| spellingShingle | Minchenko Dmytro O. Rudnytska Olha V. Khita Olena O. Kulish Yuliia V. Viletska Yuliia M. Halkin Oleh V. Danilovskyi Serhiy V. Ratushna Oksana O. Minchenko Oleksandr H. Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells Endocrine Regulations swcnts dnajb9 brca1 ddx58 mrna expression ern1 normal human astrocytes u87 glioblastoma cells |
| title | Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells |
| title_full | Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells |
| title_fullStr | Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells |
| title_full_unstemmed | Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells |
| title_short | Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells |
| title_sort | expression of dnajb9 and some other genes is more sensitive to swcnts in normal human astrocytes than glioblastoma cells |
| topic | swcnts dnajb9 brca1 ddx58 mrna expression ern1 normal human astrocytes u87 glioblastoma cells |
| url | https://doi.org/10.2478/enr-2023-0020 |
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