The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies
Abstract Circular RNAs (circRNAs) are a type of recently discovered noncoding RNA. They exert their biological functions by competitively binding to microRNAs (miRNAs) as miRNA sponges, promoting gene transcription and participating in the regulation of selective splicing, interacting with proteins...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-022-00375-3 |
| _version_ | 1811306234955956224 |
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| author | Qinfeng Zhou Dacheng Xie Rong Wang Lianfang Liu Yue Yu Xinyi Tang Yongxian Hu Dawei Cui |
| author_facet | Qinfeng Zhou Dacheng Xie Rong Wang Lianfang Liu Yue Yu Xinyi Tang Yongxian Hu Dawei Cui |
| author_sort | Qinfeng Zhou |
| collection | DOAJ |
| description | Abstract Circular RNAs (circRNAs) are a type of recently discovered noncoding RNA. They exert their biological functions by competitively binding to microRNAs (miRNAs) as miRNA sponges, promoting gene transcription and participating in the regulation of selective splicing, interacting with proteins and being translated into proteins. Exosomes are derived from intracavitary vesicles (ILVs), which are formed by the inward budding of multivesicular bodies (MVBs), and exosome release plays a pivotal role in intercellular communication. Accumulating evidence indicates that circRNAs in exosomes are associated with solid tumor invasion and metastasis. Additionally, emerging studies in the last 1 ~ 2 years have revealed that exosomal circRNA also have effect on hematological malignancies. In this review, we outline the properties and biological functions of circRNAs and exosomes. In particular, we summarize in detail the mechanism and roles of exosomal circRNAs and highlight their application as novel biomarkers in malignant tumors. |
| first_indexed | 2024-04-13T08:41:50Z |
| format | Article |
| id | doaj.art-18aa111e6e4d4c12b8147006f17acc3e |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-13T08:41:50Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-18aa111e6e4d4c12b8147006f17acc3e2022-12-22T02:53:52ZengBMCBiomarker Research2050-77712022-05-0110111510.1186/s40364-022-00375-3The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignanciesQinfeng Zhou0Dacheng Xie1Rong Wang2Lianfang Liu3Yue Yu4Xinyi Tang5Yongxian Hu6Dawei Cui7Department of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of MedicineDepartment of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Oncology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Health Sciences Research, Mayo ClinicDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu UniversityBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of MedicineAbstract Circular RNAs (circRNAs) are a type of recently discovered noncoding RNA. They exert their biological functions by competitively binding to microRNAs (miRNAs) as miRNA sponges, promoting gene transcription and participating in the regulation of selective splicing, interacting with proteins and being translated into proteins. Exosomes are derived from intracavitary vesicles (ILVs), which are formed by the inward budding of multivesicular bodies (MVBs), and exosome release plays a pivotal role in intercellular communication. Accumulating evidence indicates that circRNAs in exosomes are associated with solid tumor invasion and metastasis. Additionally, emerging studies in the last 1 ~ 2 years have revealed that exosomal circRNA also have effect on hematological malignancies. In this review, we outline the properties and biological functions of circRNAs and exosomes. In particular, we summarize in detail the mechanism and roles of exosomal circRNAs and highlight their application as novel biomarkers in malignant tumors.https://doi.org/10.1186/s40364-022-00375-3Circular RNAExosomeExosomal circular RNASolid cancersHematological malignancies |
| spellingShingle | Qinfeng Zhou Dacheng Xie Rong Wang Lianfang Liu Yue Yu Xinyi Tang Yongxian Hu Dawei Cui The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies Biomarker Research Circular RNA Exosome Exosomal circular RNA Solid cancers Hematological malignancies |
| title | The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies |
| title_full | The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies |
| title_fullStr | The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies |
| title_full_unstemmed | The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies |
| title_short | The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies |
| title_sort | emerging landscape of exosomal circrnas in solid cancers and hematological malignancies |
| topic | Circular RNA Exosome Exosomal circular RNA Solid cancers Hematological malignancies |
| url | https://doi.org/10.1186/s40364-022-00375-3 |
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