Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
In addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on <i>Cutibacterium acnes</i...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/21/6704 |
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| author | Lilian Mussi André Rolim Baby Flavio Bueno Camargo Junior Giovana Padovani Bianca da Silva Sufi Wagner Vidal Magalhães |
| author_facet | Lilian Mussi André Rolim Baby Flavio Bueno Camargo Junior Giovana Padovani Bianca da Silva Sufi Wagner Vidal Magalhães |
| author_sort | Lilian Mussi |
| collection | DOAJ |
| description | In addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on <i>Cutibacterium acnes</i>. Despite this, we investigated the existence of a synergistic effect among xylitol, caprylic acid and propanediol as a mixture of compounds representing a single topical active ingredient that could benefit the treatment against acne. In vitro and in vivo assays were performed to challenge and to prove the efficacy of propanediol, xylitol and caprylic acid (PXCA) against acne. PXCA had its MIC challenged against <i>C. acnes</i> (formerly <i>Propionibacterium acnes</i>) and <i>Staphylococcus aureus</i>, resulting in concentrations of 0.125% and 0.25%, respectively, and it also developed antimicrobial activity against <i>C. acnes</i> (time-kill test). PXCA was able to reduce the 5-alpha reductase expression in 24% (<i>p</i> < 0.01) in comparison with the testosterone group. By the end of 28 days of treatment, the compound reduced the skin oiliness, porphyrin amount and the quantity of inflammatory lesions in participants. According to the dermatologist evaluation, PXCA improved the skin’s general appearance, acne presence and size. |
| first_indexed | 2024-03-10T05:54:33Z |
| format | Article |
| id | doaj.art-18ac208429184b9b89ced7395dc33c53 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T05:54:33Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-18ac208429184b9b89ced7395dc33c532023-11-22T21:25:18ZengMDPI AGMolecules1420-30492021-11-012621670410.3390/molecules26216704Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy AssaysLilian Mussi0André Rolim Baby1Flavio Bueno Camargo Junior2Giovana Padovani3Bianca da Silva Sufi4Wagner Vidal Magalhães5Research and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, BrazilDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, 05508-000 São Paulo, BrazilResearch and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, BrazilResearch and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, BrazilResearch and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, BrazilResearch and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, BrazilIn addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on <i>Cutibacterium acnes</i>. Despite this, we investigated the existence of a synergistic effect among xylitol, caprylic acid and propanediol as a mixture of compounds representing a single topical active ingredient that could benefit the treatment against acne. In vitro and in vivo assays were performed to challenge and to prove the efficacy of propanediol, xylitol and caprylic acid (PXCA) against acne. PXCA had its MIC challenged against <i>C. acnes</i> (formerly <i>Propionibacterium acnes</i>) and <i>Staphylococcus aureus</i>, resulting in concentrations of 0.125% and 0.25%, respectively, and it also developed antimicrobial activity against <i>C. acnes</i> (time-kill test). PXCA was able to reduce the 5-alpha reductase expression in 24% (<i>p</i> < 0.01) in comparison with the testosterone group. By the end of 28 days of treatment, the compound reduced the skin oiliness, porphyrin amount and the quantity of inflammatory lesions in participants. According to the dermatologist evaluation, PXCA improved the skin’s general appearance, acne presence and size.https://www.mdpi.com/1420-3049/26/21/6704acnexylitolcaprylic acidpropanediolporphyrin5-alpha reductase |
| spellingShingle | Lilian Mussi André Rolim Baby Flavio Bueno Camargo Junior Giovana Padovani Bianca da Silva Sufi Wagner Vidal Magalhães Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays Molecules acne xylitol caprylic acid propanediol porphyrin 5-alpha reductase |
| title | Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays |
| title_full | Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays |
| title_fullStr | Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays |
| title_full_unstemmed | Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays |
| title_short | Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays |
| title_sort | propanediol and caprylic acid and xylitol as a new single topical active ingredient against acne in vitro and in vivo efficacy assays |
| topic | acne xylitol caprylic acid propanediol porphyrin 5-alpha reductase |
| url | https://www.mdpi.com/1420-3049/26/21/6704 |
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