Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapy
Background: B12 deficiency is a silent epidemic with serious consequences. Long term use of metformin has been associated with malabsorption of vitamin B12 leading to its deficiency along with increased homocysteine levels. With this background we designed this study to assess the status of vitamin...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2018-03-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/18806 |
| _version_ | 1819104289377746944 |
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| author | Ananda Vayaravel Cassinadane Ramesh Ramaswamy Shaik Anwar Hussain Radhika Govindarajan Abu Raghavan Srinivasan |
| author_facet | Ananda Vayaravel Cassinadane Ramesh Ramaswamy Shaik Anwar Hussain Radhika Govindarajan Abu Raghavan Srinivasan |
| author_sort | Ananda Vayaravel Cassinadane |
| collection | DOAJ |
| description | Background: B12 deficiency is a silent epidemic with serious consequences. Long term use of metformin has been associated with malabsorption of vitamin B12 leading to its deficiency along with increased homocysteine levels. With this background we designed this study to assess the status of vitamin B12 and its markers in type 2 diabetes mellitus patients on metformin therapy who are attending tertiary care hospital in the peripheral area of Pondicherry.
Aims and Objective: The current study aims to study the relationship if any, between the glycemic status and the status of Vitamin B12 among T2DM patients on metformin therapy.
Materials and Methods: A case control study was done with a sample size of 100 (50 case and 50 control). The patients were selected according to the inclusion criteria and their blood sample were analyzed for the various parameters. The markers of vitamin B12 status are studied among both the control and the patients with T2DM on metformin therapy and compared with their glycaemic status.
Results: There is a significant increase in the levels of FBS, HbA1c, insulin and C-peptide in the study group. It was observed that the mean levels of homocysteine and Methylmalonic acid were significantly higher with lower levels of vitamin B12 in patients who were on metformin therapy.
Conclusion: There is moderate correlation between the markers of B12 status and levels of fasting blood sugar as well as HbA1C. There is a significant correlation between insulin and C-peptide with the markers of vitamin B12 status. |
| first_indexed | 2024-12-22T02:03:59Z |
| format | Article |
| id | doaj.art-18ac2542083d4e50bb0b5d0574717a6e |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-22T02:03:59Z |
| publishDate | 2018-03-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-18ac2542083d4e50bb0b5d0574717a6e2022-12-21T18:42:35ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762018-03-0192912https://doi.org/10.3126/ajms.v9i2.18806Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapyAnanda Vayaravel Cassinadane 0Ramesh Ramaswamy1Shaik Anwar Hussain 2Radhika Govindarajan3Abu Raghavan Srinivasan4Tutor cum PhD scholar, Department of Biochemistry, Sri Venkateshwaraa Medical College Hospital and Research Centre (SVMCHRC), Ariyur, Puducherry http://orcid.org/0000-0002-2103-8417Professor and Head, Department of Biochemistry, JIPMER, Karaikal, Puducherry http://orcid.org/0000-0002-6939-4453Associate Professor, Department of Medicine, Sri Venkateshwaraa Medical College Hospital and Research Centre (SVMCHRC), Ariyur, Puducherry http://orcid.org/0000-0003-1411-7093Professor and Head, Department of Biochemistry, Sri Venkateshwaraa Medical College Hospital and Research Centre (SVMCHRC), Ariyur, Puducherry http://orcid.org/0000-0002-5361-7595Professor, Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (SBV) University, Puducherry http://orcid.org/0000-0001-5775-272XBackground: B12 deficiency is a silent epidemic with serious consequences. Long term use of metformin has been associated with malabsorption of vitamin B12 leading to its deficiency along with increased homocysteine levels. With this background we designed this study to assess the status of vitamin B12 and its markers in type 2 diabetes mellitus patients on metformin therapy who are attending tertiary care hospital in the peripheral area of Pondicherry. Aims and Objective: The current study aims to study the relationship if any, between the glycemic status and the status of Vitamin B12 among T2DM patients on metformin therapy. Materials and Methods: A case control study was done with a sample size of 100 (50 case and 50 control). The patients were selected according to the inclusion criteria and their blood sample were analyzed for the various parameters. The markers of vitamin B12 status are studied among both the control and the patients with T2DM on metformin therapy and compared with their glycaemic status. Results: There is a significant increase in the levels of FBS, HbA1c, insulin and C-peptide in the study group. It was observed that the mean levels of homocysteine and Methylmalonic acid were significantly higher with lower levels of vitamin B12 in patients who were on metformin therapy. Conclusion: There is moderate correlation between the markers of B12 status and levels of fasting blood sugar as well as HbA1C. There is a significant correlation between insulin and C-peptide with the markers of vitamin B12 status.https://www.nepjol.info/index.php/AJMS/article/view/18806b12 deficiency markersglycemic statusmetforminvitamin b12 deficiencytype 2 diabetes mellitus |
| spellingShingle | Ananda Vayaravel Cassinadane Ramesh Ramaswamy Shaik Anwar Hussain Radhika Govindarajan Abu Raghavan Srinivasan Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapy Asian Journal of Medical Sciences b12 deficiency markers glycemic status metformin vitamin b12 deficiency type 2 diabetes mellitus |
| title | Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapy |
| title_full | Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapy |
| title_fullStr | Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapy |
| title_full_unstemmed | Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapy |
| title_short | Evaluation of Vitamin B12 status in type 2 Diabetes Mellitus Patients on Metformin therapy |
| title_sort | evaluation of vitamin b12 status in type 2 diabetes mellitus patients on metformin therapy |
| topic | b12 deficiency markers glycemic status metformin vitamin b12 deficiency type 2 diabetes mellitus |
| url | https://www.nepjol.info/index.php/AJMS/article/view/18806 |
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