Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis
Abstract Thrombotic cardio‐cerebrovascular diseases seriously threaten human health. Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off‐target bleeding risks of most thrombolytic drugs, resulting in unsatisfactory treatm...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-02-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202104264 |
| _version_ | 1818082942096769024 |
|---|---|
| author | Zhiqiang Zhao Xuanbo Zhang Hongyuan Zhang Xinzhu Shan Meiyu Bai Zhe Wang Fujun Yang Haotian Zhang Qiming Kan Bingjun Sun Jin Sun Zhonggui He Cong Luo |
| author_facet | Zhiqiang Zhao Xuanbo Zhang Hongyuan Zhang Xinzhu Shan Meiyu Bai Zhe Wang Fujun Yang Haotian Zhang Qiming Kan Bingjun Sun Jin Sun Zhonggui He Cong Luo |
| author_sort | Zhiqiang Zhao |
| collection | DOAJ |
| description | Abstract Thrombotic cardio‐cerebrovascular diseases seriously threaten human health. Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off‐target bleeding risks of most thrombolytic drugs, resulting in unsatisfactory treatment outcomes. Herein, it is proposed that these challenges can be overcome by precisely integrating the conventional thrombolytic strategy with photothermal therapy. After co‐assembly engineering optimization, a fibrin‐targeting peptide‐decorated nanoassembly of DiR (a photothermal probe) and ticagrelor (TGL, an antiplatelet drug) is prepared for thrombus‐homing delivery, abbreviated as FT‐DT NPs. The elaborately engineered nanoassembly shows multiple advantages, including simple preparation with high drug co‐loading capacity, synchronous delivery of two drugs with long systemic circulation, thrombus‐targeted accumulation with self‐indicating function, as well as photothermal‐potentiated thrombus penetration and thrombolysis with high therapeutic efficacy. As expected, FT‐DT NPs not only show bright fluorescence signals in the embolized vessels, but also perform photothermal/antiplatelet synergistic thrombolysis in vivo. This study offers a simple and versatile co‐delivery nanoplatform for imaging‐guided photothermal/antiplatelet dual‐modality thrombolysis. |
| first_indexed | 2024-12-10T19:30:06Z |
| format | Article |
| id | doaj.art-18b2ec3a3f164654825cbca64be3e91b |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T19:30:06Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-18b2ec3a3f164654825cbca64be3e91b2022-12-22T01:36:16ZengWileyAdvanced Science2198-38442022-02-0194n/an/a10.1002/advs.202104264Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and ThrombolysisZhiqiang Zhao0Xuanbo Zhang1Hongyuan Zhang2Xinzhu Shan3Meiyu Bai4Zhe Wang5Fujun Yang6Haotian Zhang7Qiming Kan8Bingjun Sun9Jin Sun10Zhonggui He11Cong Luo12Department of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaSchool of Life Science and Biopharmaceutics Shenyang Pharmaceutical University Shenyang 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaSchool of Life Science and Biopharmaceutics Shenyang Pharmaceutical University Shenyang 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaDepartment of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang Liaoning 110016 P. R. ChinaAbstract Thrombotic cardio‐cerebrovascular diseases seriously threaten human health. Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off‐target bleeding risks of most thrombolytic drugs, resulting in unsatisfactory treatment outcomes. Herein, it is proposed that these challenges can be overcome by precisely integrating the conventional thrombolytic strategy with photothermal therapy. After co‐assembly engineering optimization, a fibrin‐targeting peptide‐decorated nanoassembly of DiR (a photothermal probe) and ticagrelor (TGL, an antiplatelet drug) is prepared for thrombus‐homing delivery, abbreviated as FT‐DT NPs. The elaborately engineered nanoassembly shows multiple advantages, including simple preparation with high drug co‐loading capacity, synchronous delivery of two drugs with long systemic circulation, thrombus‐targeted accumulation with self‐indicating function, as well as photothermal‐potentiated thrombus penetration and thrombolysis with high therapeutic efficacy. As expected, FT‐DT NPs not only show bright fluorescence signals in the embolized vessels, but also perform photothermal/antiplatelet synergistic thrombolysis in vivo. This study offers a simple and versatile co‐delivery nanoplatform for imaging‐guided photothermal/antiplatelet dual‐modality thrombolysis.https://doi.org/10.1002/advs.202104264antiplateletdual‐drug nanoassemblyphotothermal thrombolysissite‐specific synergistic thrombolysisthrombus penetration |
| spellingShingle | Zhiqiang Zhao Xuanbo Zhang Hongyuan Zhang Xinzhu Shan Meiyu Bai Zhe Wang Fujun Yang Haotian Zhang Qiming Kan Bingjun Sun Jin Sun Zhonggui He Cong Luo Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis Advanced Science antiplatelet dual‐drug nanoassembly photothermal thrombolysis site‐specific synergistic thrombolysis thrombus penetration |
| title | Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis |
| title_full | Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis |
| title_fullStr | Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis |
| title_full_unstemmed | Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis |
| title_short | Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis |
| title_sort | elaborately engineering a self indicating dual drug nanoassembly for site specific photothermal potentiated thrombus penetration and thrombolysis |
| topic | antiplatelet dual‐drug nanoassembly photothermal thrombolysis site‐specific synergistic thrombolysis thrombus penetration |
| url | https://doi.org/10.1002/advs.202104264 |
| work_keys_str_mv | AT zhiqiangzhao elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT xuanbozhang elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT hongyuanzhang elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT xinzhushan elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT meiyubai elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT zhewang elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT fujunyang elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT haotianzhang elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT qimingkan elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT bingjunsun elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT jinsun elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT zhongguihe elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis AT congluo elaboratelyengineeringaselfindicatingdualdrugnanoassemblyforsitespecificphotothermalpotentiatedthrombuspenetrationandthrombolysis |