Neuroretinal dysfunction in patients affected by neurofibromatosis type 1
AIM: To examine neuroretinal function by using the multifocal electroretinography (mfERG) test in patients with neurofibromatosis type 1 (NF1) without optic pathway gliomas (OPGs). METHODS: This study was conducted on 35 patients (35 eyes) with NF1 and 30 healthy subjects (30 eyes) for the control g...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-05-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2022/5/20220513.pdf |
| _version_ | 1828491832059756544 |
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| author | Antonietta Moramarco Luca Lucchino Fabiana Mallone Michela Marcelli Ludovico Alisi Vincenzo Roberti Sandra Giustini Alessandro Lambiase Marcella Nebbioso |
| author_facet | Antonietta Moramarco Luca Lucchino Fabiana Mallone Michela Marcelli Ludovico Alisi Vincenzo Roberti Sandra Giustini Alessandro Lambiase Marcella Nebbioso |
| author_sort | Antonietta Moramarco |
| collection | DOAJ |
| description | AIM: To examine neuroretinal function by using the multifocal electroretinography (mfERG) test in patients with neurofibromatosis type 1 (NF1) without optic pathway gliomas (OPGs). METHODS: This study was conducted on 35 patients (35 eyes) with NF1 and 30 healthy subjects (30 eyes) for the control group. Each subject underwent a complete ophthalmological examination including spectral domain-optical coherence tomography (SD-OCT) and mfERG. The 1.5-Tesla magnetic resonance imaging (MRI) scan of the brain was performed in NF1 patients to assess the presence of OPGs. All participants were recruited having a best corrected visual acuity (BCVA) of no less than 20/20 in each eye. The amplitude and implicit time of the P1 wave (first-order Kernel component) were evaluated on mfERG. Data analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual field. RESULTS: Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls, while the reduction was not significant in the 2 central degrees between the groups. A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group, with lower amplitudes detected in the nasal quadrants. No differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and controls. CONCLUSION: Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mfERG. Altered intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate (cAMP) generation, can be involved. The possible use of mfERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients. |
| first_indexed | 2024-12-11T11:09:42Z |
| format | Article |
| id | doaj.art-18b81dfe1e4e440ebb4b73a75702903e |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-11T11:09:42Z |
| publishDate | 2022-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-18b81dfe1e4e440ebb4b73a75702903e2022-12-22T01:09:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982022-05-0115577377910.18240/ijo.2022.05.1320220513Neuroretinal dysfunction in patients affected by neurofibromatosis type 1Antonietta Moramarco0Luca Lucchino1Fabiana Mallone2Michela Marcelli3Ludovico Alisi4Vincenzo Roberti5Sandra Giustini6Alessandro Lambiase7Marcella Nebbioso8Alessandro Lambiase. Ophthalmology at Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy. Alessandro.lambiase@uniroma1.itDepartment of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyDepartment of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyDepartment of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyDepartment of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyDepartment of Dermatology and Venereology, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyDepartment of Dermatology and Venereology, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyDepartment of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyDepartment of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, ItalyAIM: To examine neuroretinal function by using the multifocal electroretinography (mfERG) test in patients with neurofibromatosis type 1 (NF1) without optic pathway gliomas (OPGs). METHODS: This study was conducted on 35 patients (35 eyes) with NF1 and 30 healthy subjects (30 eyes) for the control group. Each subject underwent a complete ophthalmological examination including spectral domain-optical coherence tomography (SD-OCT) and mfERG. The 1.5-Tesla magnetic resonance imaging (MRI) scan of the brain was performed in NF1 patients to assess the presence of OPGs. All participants were recruited having a best corrected visual acuity (BCVA) of no less than 20/20 in each eye. The amplitude and implicit time of the P1 wave (first-order Kernel component) were evaluated on mfERG. Data analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual field. RESULTS: Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls, while the reduction was not significant in the 2 central degrees between the groups. A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group, with lower amplitudes detected in the nasal quadrants. No differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and controls. CONCLUSION: Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mfERG. Altered intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate (cAMP) generation, can be involved. The possible use of mfERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.http://ies.ijo.cn/en_publish/2022/5/20220513.pdfneurofibromatosis type 1multifocal electroretinographyneuroretinal functionoptic pathway gliomasneurofibromin |
| spellingShingle | Antonietta Moramarco Luca Lucchino Fabiana Mallone Michela Marcelli Ludovico Alisi Vincenzo Roberti Sandra Giustini Alessandro Lambiase Marcella Nebbioso Neuroretinal dysfunction in patients affected by neurofibromatosis type 1 International Journal of Ophthalmology neurofibromatosis type 1 multifocal electroretinography neuroretinal function optic pathway gliomas neurofibromin |
| title | Neuroretinal dysfunction in patients affected by neurofibromatosis type 1 |
| title_full | Neuroretinal dysfunction in patients affected by neurofibromatosis type 1 |
| title_fullStr | Neuroretinal dysfunction in patients affected by neurofibromatosis type 1 |
| title_full_unstemmed | Neuroretinal dysfunction in patients affected by neurofibromatosis type 1 |
| title_short | Neuroretinal dysfunction in patients affected by neurofibromatosis type 1 |
| title_sort | neuroretinal dysfunction in patients affected by neurofibromatosis type 1 |
| topic | neurofibromatosis type 1 multifocal electroretinography neuroretinal function optic pathway gliomas neurofibromin |
| url | http://ies.ijo.cn/en_publish/2022/5/20220513.pdf |
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