Senescent CD4<sup>+</sup>CD28<sup>−</sup> T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis

Senescent CD4<sup>+</sup>CD28<sup>−</sup> T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis

Senescent cells express a senescence-associated secretory phenotype (SASP) with a pro-inflammatory bias, which contributes to the chronicity of inflammation. During chronic inflammatory diseases, infiltrating CD4<sup>+</sup> T lymphocytes can undergo cellular senescence and arrest the su...

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Bibliographic Details
Main Authors: Luis González-Osuna, Alfredo Sierra-Cristancho, Emilio A. Cafferata, Samanta Melgar-Rodríguez, Carolina Rojas, Paola Carvajal, Cristian Cortez, Rolando Vernal
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
cell senescence
T-lymphocytes
CD28
periodontitis
alveolar bone loss
Th17 lymphocytes
Online Access:https://www.mdpi.com/1422-0067/23/5/2543

Internet

https://www.mdpi.com/1422-0067/23/5/2543

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