Hormones of stress and coronary syndrome X (experimental research)
Experiments studies which showed are carried out that stress hormones (a cortisol, adrenaline) can bind to erythrocyte membranes with high affinity, leading to rough structural changes. The last are accompanied by increase of microviscosity of membranes as in area a lipid-lipid, and protein-lipid of...
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Format: | Article |
Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2012-12-01
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Series: | Атеросклероз |
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Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/648/585 |
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author | L. E. Panin P. V. Mokrushnikov R. A. Knjazev A. R. Kolpakov B. N. Zajitsev |
author_facet | L. E. Panin P. V. Mokrushnikov R. A. Knjazev A. R. Kolpakov B. N. Zajitsev |
author_sort | L. E. Panin |
collection | DOAJ |
description | Experiments studies which showed are carried out that stress hormones (a cortisol, adrenaline) can bind to erythrocyte membranes with high affinity, leading to rough structural changes. The last are accompanied by increase of microviscosity of membranes as in area a lipid-lipid, and protein-lipid of interactions. The nature of these changes is caused by simultaneous interaction of active groups of hormones (NH, OH and their waterproof rings) at the same time with a lipid and protein components of a membrane with formation of domains. Experiments with heart perfusion of rats showed that erythrocytes with the increased microviscosity of their membranes are incapable to move ahead on the capillary course that leads to sharp decrease in a coronary stream and fast cardiac arrest. The assumption is come out that this mechanism is shown and at a coronary syndrome X at the person. |
first_indexed | 2024-04-11T02:04:49Z |
format | Article |
id | doaj.art-18b8b0752d9d40419420f68d32ab859f |
institution | Directory Open Access Journal |
issn | 2078-256X |
language | Russian |
last_indexed | 2024-04-11T02:04:49Z |
publishDate | 2012-12-01 |
publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
record_format | Article |
series | Атеросклероз |
spelling | doaj.art-18b8b0752d9d40419420f68d32ab859f2023-01-03T03:11:20ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2012-12-0182513Hormones of stress and coronary syndrome X (experimental research)L. E. Panin0P. V. Mokrushnikov1R. A. Knjazev2A. R. Kolpakov3B. N. Zajitsev4RAMS Russian Federation SB RAMS Federal state budgetary institution "Research Institute of Biochemistry"RAMS Russian Federation SB RAMS Federal state budgetary institution "Research Institute of Biochemistry"RAMS Russian Federation SB RAMS Federal state budgetary institution "Research Institute of Biochemistry"RAMS Russian Federation SB RAMS Federal state budgetary institution "Research Institute of Biochemistry"Rospotrebnadzor Russian Federation Federal Budgetary Institution of Science State Scientific Center for Virology and Biotechnology "Vector"Experiments studies which showed are carried out that stress hormones (a cortisol, adrenaline) can bind to erythrocyte membranes with high affinity, leading to rough structural changes. The last are accompanied by increase of microviscosity of membranes as in area a lipid-lipid, and protein-lipid of interactions. The nature of these changes is caused by simultaneous interaction of active groups of hormones (NH, OH and their waterproof rings) at the same time with a lipid and protein components of a membrane with formation of domains. Experiments with heart perfusion of rats showed that erythrocytes with the increased microviscosity of their membranes are incapable to move ahead on the capillary course that leads to sharp decrease in a coronary stream and fast cardiac arrest. The assumption is come out that this mechanism is shown and at a coronary syndrome X at the person.https://ateroskleroz.elpub.ru/jour/article/view/648/585coronary syndrome xmicroviscosity of membranesstress hormonesstructural changes of membranes of erythrocytes |
spellingShingle | L. E. Panin P. V. Mokrushnikov R. A. Knjazev A. R. Kolpakov B. N. Zajitsev Hormones of stress and coronary syndrome X (experimental research) Атеросклероз coronary syndrome x microviscosity of membranes stress hormones structural changes of membranes of erythrocytes |
title | Hormones of stress and coronary syndrome X (experimental research) |
title_full | Hormones of stress and coronary syndrome X (experimental research) |
title_fullStr | Hormones of stress and coronary syndrome X (experimental research) |
title_full_unstemmed | Hormones of stress and coronary syndrome X (experimental research) |
title_short | Hormones of stress and coronary syndrome X (experimental research) |
title_sort | hormones of stress and coronary syndrome x experimental research |
topic | coronary syndrome x microviscosity of membranes stress hormones structural changes of membranes of erythrocytes |
url | https://ateroskleroz.elpub.ru/jour/article/view/648/585 |
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