Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects
Purpose High sodium intake is an accepted risk factor for hypertension, while low Na+ intake has also been associated with increased risk of cardiovascular events. In this cross-sectional study, we examined the association of 24-h urinary Na+ excretion with haemodynamics and volume status. Materials...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Blood Pressure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08037051.2023.2170869 |
| _version_ | 1797676798814715904 |
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| author | Jyrki Taurio Jenni Koskela Marjatta Sinisalo Antti Tikkakoski Onni Niemelä Mari Hämäläinen Eeva Moilanen Manoj Kumar Choudhary Jukka Mustonen Pasi Nevalainen Ilkka Pörsti |
| author_facet | Jyrki Taurio Jenni Koskela Marjatta Sinisalo Antti Tikkakoski Onni Niemelä Mari Hämäläinen Eeva Moilanen Manoj Kumar Choudhary Jukka Mustonen Pasi Nevalainen Ilkka Pörsti |
| author_sort | Jyrki Taurio |
| collection | DOAJ |
| description | Purpose High sodium intake is an accepted risk factor for hypertension, while low Na+ intake has also been associated with increased risk of cardiovascular events. In this cross-sectional study, we examined the association of 24-h urinary Na+ excretion with haemodynamics and volume status. Materials and methods Haemodynamics were recorded in 510 normotensive and never-treated hypertensive subjects using whole-body impedance cardiography and tonometric radial artery pulse wave analysis. The results were examined in sex-specific tertiles of 24-h Na+ excretion, and comparisons between normotensive and hypertensive participants were also performed. Regression analysis was used to investigate factors associated with volume status. The findings were additionally compared to 28 patients with primary aldosteronism. Results The mean values of 24-h urinary Na+ excretion in tertiles of the 510 participants were 94, 148 and 218 mmol, respectively. Average tertile age (43.4–44.7 years), office blood pressure and pulse wave velocity were corresponding in the tertiles. Plasma electrolytes, lipids, vitamin D metabolites, parathyroid hormone, renin activity, aldosterone, creatinine and insulin sensitivity did not differ in the tertiles. In supine laboratory recordings, there were no differences in aortic systolic and diastolic blood pressure, heart rate, cardiac output and systemic vascular resistance. Extracellular water volume was higher in the highest versus lowest tertile of Na+ excretion. In regression analysis, body surface area and 24-h Na+ excretion were independent explanatory variables for extracellular water volume. No differences in urine Na+ excretion and extracellular water volume were found between normotensive and hypertensive participants. When compared with the 510 participants, patients with primary aldosteronism had 6.0% excess in extracellular water (p = .003), and 24-h Na+ excretion was not related with extracellular water volume. Conclusion In the absence of mineralocorticoid excess, Na+ intake, as evaluated from 24-h Na+ excretion, predominantly influences extracellular water volume without a clear effect on blood pressure. |
| first_indexed | 2024-03-11T22:35:34Z |
| format | Article |
| id | doaj.art-18b8f030bd9847cbbad758985d225946 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-11T22:35:34Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-18b8f030bd9847cbbad758985d2259462023-09-22T13:57:06ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992023-12-0132110.1080/08037051.2023.21708692170869Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjectsJyrki Taurio0Jenni Koskela1Marjatta Sinisalo2Antti Tikkakoski3Onni Niemelä4Mari Hämäläinen5Eeva Moilanen6Manoj Kumar Choudhary7Jukka Mustonen8Pasi Nevalainen9Ilkka Pörsti10Faculty of Medicine and Health Technology, Tampere UniversityFaculty of Medicine and Health Technology, Tampere UniversityDepartment of Internal Medicine, Tampere University HospitalFaculty of Medicine and Health Technology, Tampere UniversityDepartment of Laboratory Medicine and Medical Research Unit, Seinäjoki Central HospitalFaculty of Medicine and Health Technology, Tampere UniversityFaculty of Medicine and Health Technology, Tampere UniversityFaculty of Medicine and Health Technology, Tampere UniversityFaculty of Medicine and Health Technology, Tampere UniversityDepartment of Internal Medicine, Tampere University HospitalFaculty of Medicine and Health Technology, Tampere UniversityPurpose High sodium intake is an accepted risk factor for hypertension, while low Na+ intake has also been associated with increased risk of cardiovascular events. In this cross-sectional study, we examined the association of 24-h urinary Na+ excretion with haemodynamics and volume status. Materials and methods Haemodynamics were recorded in 510 normotensive and never-treated hypertensive subjects using whole-body impedance cardiography and tonometric radial artery pulse wave analysis. The results were examined in sex-specific tertiles of 24-h Na+ excretion, and comparisons between normotensive and hypertensive participants were also performed. Regression analysis was used to investigate factors associated with volume status. The findings were additionally compared to 28 patients with primary aldosteronism. Results The mean values of 24-h urinary Na+ excretion in tertiles of the 510 participants were 94, 148 and 218 mmol, respectively. Average tertile age (43.4–44.7 years), office blood pressure and pulse wave velocity were corresponding in the tertiles. Plasma electrolytes, lipids, vitamin D metabolites, parathyroid hormone, renin activity, aldosterone, creatinine and insulin sensitivity did not differ in the tertiles. In supine laboratory recordings, there were no differences in aortic systolic and diastolic blood pressure, heart rate, cardiac output and systemic vascular resistance. Extracellular water volume was higher in the highest versus lowest tertile of Na+ excretion. In regression analysis, body surface area and 24-h Na+ excretion were independent explanatory variables for extracellular water volume. No differences in urine Na+ excretion and extracellular water volume were found between normotensive and hypertensive participants. When compared with the 510 participants, patients with primary aldosteronism had 6.0% excess in extracellular water (p = .003), and 24-h Na+ excretion was not related with extracellular water volume. Conclusion In the absence of mineralocorticoid excess, Na+ intake, as evaluated from 24-h Na+ excretion, predominantly influences extracellular water volume without a clear effect on blood pressure.http://dx.doi.org/10.1080/08037051.2023.2170869blood pressureextracellular water volumepulse wave analysissodium excretionwhole-body impedance cardiography |
| spellingShingle | Jyrki Taurio Jenni Koskela Marjatta Sinisalo Antti Tikkakoski Onni Niemelä Mari Hämäläinen Eeva Moilanen Manoj Kumar Choudhary Jukka Mustonen Pasi Nevalainen Ilkka Pörsti Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects Blood Pressure blood pressure extracellular water volume pulse wave analysis sodium excretion whole-body impedance cardiography |
| title | Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects |
| title_full | Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects |
| title_fullStr | Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects |
| title_full_unstemmed | Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects |
| title_short | Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects |
| title_sort | urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never treated hypertensive subjects |
| topic | blood pressure extracellular water volume pulse wave analysis sodium excretion whole-body impedance cardiography |
| url | http://dx.doi.org/10.1080/08037051.2023.2170869 |
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