Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling
Angiotensin II (Ang II) is the primary modulator of the renin-angiotensin system and has been widely studied for its effect on the cardiovascular system. While a few studies have also indicated an involvement of Ang II in the regulation of breathing, very little is known in this regard and its effec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1111263/full |
| _version_ | 1797934872646385664 |
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| author | Charlotte Tacke Anne M. Bischoff Ali Harb Behnam Vafadari Swen Hülsmann |
| author_facet | Charlotte Tacke Anne M. Bischoff Ali Harb Behnam Vafadari Swen Hülsmann |
| author_sort | Charlotte Tacke |
| collection | DOAJ |
| description | Angiotensin II (Ang II) is the primary modulator of the renin-angiotensin system and has been widely studied for its effect on the cardiovascular system. While a few studies have also indicated an involvement of Ang II in the regulation of breathing, very little is known in this regard and its effect on brainstem respiratory regions such as the preBötzinger complex (preBötC), the kernel for inspiratory rhythm generation, has not been investigated yet. This study reports that Ang II temporarily increases phrenic nerve activity in the working heart-brainstem preparation, indicating higher central respiratory drive. Previous studies have shown that the carotid body is involved in mediating this effect and we revealed that the preBötC also plays a part, using acute slices of the brainstem. It appears that Ang II is increasing the respiratory drive in an AT1R-dependent manner by optimizing the interaction of inhibitory and excitatory neurons of the preBötC. Thus, Ang II-mediated effects on the preBötC are potentially involved in dysregulating breathing in patients with acute lung injury. |
| first_indexed | 2024-04-10T18:05:41Z |
| format | Article |
| id | doaj.art-18bac9eb301c41a7839fc2f5fc9d2722 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-10T18:05:41Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-18bac9eb301c41a7839fc2f5fc9d27222023-02-02T13:08:24ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-02-011710.3389/fncel.2023.11112631111263Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signalingCharlotte TackeAnne M. BischoffAli HarbBehnam VafadariSwen HülsmannAngiotensin II (Ang II) is the primary modulator of the renin-angiotensin system and has been widely studied for its effect on the cardiovascular system. While a few studies have also indicated an involvement of Ang II in the regulation of breathing, very little is known in this regard and its effect on brainstem respiratory regions such as the preBötzinger complex (preBötC), the kernel for inspiratory rhythm generation, has not been investigated yet. This study reports that Ang II temporarily increases phrenic nerve activity in the working heart-brainstem preparation, indicating higher central respiratory drive. Previous studies have shown that the carotid body is involved in mediating this effect and we revealed that the preBötC also plays a part, using acute slices of the brainstem. It appears that Ang II is increasing the respiratory drive in an AT1R-dependent manner by optimizing the interaction of inhibitory and excitatory neurons of the preBötC. Thus, Ang II-mediated effects on the preBötC are potentially involved in dysregulating breathing in patients with acute lung injury.https://www.frontiersin.org/articles/10.3389/fncel.2023.1111263/fullpreBötzinger complex (preBötC)angiotensin IIrespirationrespiratory activityastrocytes |
| spellingShingle | Charlotte Tacke Anne M. Bischoff Ali Harb Behnam Vafadari Swen Hülsmann Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling Frontiers in Cellular Neuroscience preBötzinger complex (preBötC) angiotensin II respiration respiratory activity astrocytes |
| title | Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling |
| title_full | Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling |
| title_fullStr | Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling |
| title_full_unstemmed | Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling |
| title_short | Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling |
| title_sort | angiotensin ii increases respiratory rhythmic activity in the prebotzinger complex without inducing astroglial calcium signaling |
| topic | preBötzinger complex (preBötC) angiotensin II respiration respiratory activity astrocytes |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1111263/full |
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