Structural basis for delta cell paracrine regulation in pancreatic islets

Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approa...

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Main Authors: Rafael Arrojo e Drigo, Stefan Jacob, Concha F. García-Prieto, Xiaofeng Zheng, Masahiro Fukuda, Hoa Tran Thi Nhu, Olga Stelmashenko, Flavia Letícia Martins Peçanha, Rayner Rodriguez-Diaz, Eric Bushong, Thomas Deerinck, Sebastien Phan, Yusuf Ali, Ingo Leibiger, Minni Chua, Thomas Boudier, Sang-Ho Song, Martin Graf, George J. Augustine, Mark H. Ellisman, Per-Olof Berggren
Format: Article
Language:English
Published: Nature Portfolio 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11517-x
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author Rafael Arrojo e Drigo
Stefan Jacob
Concha F. García-Prieto
Xiaofeng Zheng
Masahiro Fukuda
Hoa Tran Thi Nhu
Olga Stelmashenko
Flavia Letícia Martins Peçanha
Rayner Rodriguez-Diaz
Eric Bushong
Thomas Deerinck
Sebastien Phan
Yusuf Ali
Ingo Leibiger
Minni Chua
Thomas Boudier
Sang-Ho Song
Martin Graf
George J. Augustine
Mark H. Ellisman
Per-Olof Berggren
author_facet Rafael Arrojo e Drigo
Stefan Jacob
Concha F. García-Prieto
Xiaofeng Zheng
Masahiro Fukuda
Hoa Tran Thi Nhu
Olga Stelmashenko
Flavia Letícia Martins Peçanha
Rayner Rodriguez-Diaz
Eric Bushong
Thomas Deerinck
Sebastien Phan
Yusuf Ali
Ingo Leibiger
Minni Chua
Thomas Boudier
Sang-Ho Song
Martin Graf
George J. Augustine
Mark H. Ellisman
Per-Olof Berggren
author_sort Rafael Arrojo e Drigo
collection DOAJ
description Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches.
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spelling doaj.art-18bb2e2d712b47329b5a77a1642cf62e2022-12-21T23:00:38ZengNature PortfolioNature Communications2041-17232019-08-0110111210.1038/s41467-019-11517-xStructural basis for delta cell paracrine regulation in pancreatic isletsRafael Arrojo e Drigo0Stefan Jacob1Concha F. García-Prieto2Xiaofeng Zheng3Masahiro Fukuda4Hoa Tran Thi Nhu5Olga Stelmashenko6Flavia Letícia Martins Peçanha7Rayner Rodriguez-Diaz8Eric Bushong9Thomas Deerinck10Sebastien Phan11Yusuf Ali12Ingo Leibiger13Minni Chua14Thomas Boudier15Sang-Ho Song16Martin Graf17George J. Augustine18Mark H. Ellisman19Per-Olof Berggren20Lee Kong Chian School of Medicine, Nanyang Technological UniversityKarolinska Intitutet, The Rolf Luft Research Center for Diabetes and EndocrinologyKarolinska Intitutet, The Rolf Luft Research Center for Diabetes and EndocrinologyLee Kong Chian School of Medicine, Nanyang Technological UniversityMolecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical SchoolBioinformatics Institute (ASTAR) and Image and Pervasive Access Lab (IPAL)Lee Kong Chian School of Medicine, Nanyang Technological UniversityUniversidade Federal do Rio de Janeiro (UFRJ)Miller School of Medicine, University of MiamiNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoLee Kong Chian School of Medicine, Nanyang Technological UniversityKarolinska Intitutet, The Rolf Luft Research Center for Diabetes and EndocrinologyLee Kong Chian School of Medicine, Nanyang Technological UniversityBioinformatics Institute (ASTAR) and Image and Pervasive Access Lab (IPAL)Lee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoLee Kong Chian School of Medicine, Nanyang Technological UniversityPancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches.https://doi.org/10.1038/s41467-019-11517-x
spellingShingle Rafael Arrojo e Drigo
Stefan Jacob
Concha F. García-Prieto
Xiaofeng Zheng
Masahiro Fukuda
Hoa Tran Thi Nhu
Olga Stelmashenko
Flavia Letícia Martins Peçanha
Rayner Rodriguez-Diaz
Eric Bushong
Thomas Deerinck
Sebastien Phan
Yusuf Ali
Ingo Leibiger
Minni Chua
Thomas Boudier
Sang-Ho Song
Martin Graf
George J. Augustine
Mark H. Ellisman
Per-Olof Berggren
Structural basis for delta cell paracrine regulation in pancreatic islets
Nature Communications
title Structural basis for delta cell paracrine regulation in pancreatic islets
title_full Structural basis for delta cell paracrine regulation in pancreatic islets
title_fullStr Structural basis for delta cell paracrine regulation in pancreatic islets
title_full_unstemmed Structural basis for delta cell paracrine regulation in pancreatic islets
title_short Structural basis for delta cell paracrine regulation in pancreatic islets
title_sort structural basis for delta cell paracrine regulation in pancreatic islets
url https://doi.org/10.1038/s41467-019-11517-x
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