Structural basis for delta cell paracrine regulation in pancreatic islets
Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approa...
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2019-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11517-x |
_version_ | 1818420284929081344 |
---|---|
author | Rafael Arrojo e Drigo Stefan Jacob Concha F. García-Prieto Xiaofeng Zheng Masahiro Fukuda Hoa Tran Thi Nhu Olga Stelmashenko Flavia Letícia Martins Peçanha Rayner Rodriguez-Diaz Eric Bushong Thomas Deerinck Sebastien Phan Yusuf Ali Ingo Leibiger Minni Chua Thomas Boudier Sang-Ho Song Martin Graf George J. Augustine Mark H. Ellisman Per-Olof Berggren |
author_facet | Rafael Arrojo e Drigo Stefan Jacob Concha F. García-Prieto Xiaofeng Zheng Masahiro Fukuda Hoa Tran Thi Nhu Olga Stelmashenko Flavia Letícia Martins Peçanha Rayner Rodriguez-Diaz Eric Bushong Thomas Deerinck Sebastien Phan Yusuf Ali Ingo Leibiger Minni Chua Thomas Boudier Sang-Ho Song Martin Graf George J. Augustine Mark H. Ellisman Per-Olof Berggren |
author_sort | Rafael Arrojo e Drigo |
collection | DOAJ |
description | Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches. |
first_indexed | 2024-12-14T12:52:02Z |
format | Article |
id | doaj.art-18bb2e2d712b47329b5a77a1642cf62e |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-12-14T12:52:02Z |
publishDate | 2019-08-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-18bb2e2d712b47329b5a77a1642cf62e2022-12-21T23:00:38ZengNature PortfolioNature Communications2041-17232019-08-0110111210.1038/s41467-019-11517-xStructural basis for delta cell paracrine regulation in pancreatic isletsRafael Arrojo e Drigo0Stefan Jacob1Concha F. García-Prieto2Xiaofeng Zheng3Masahiro Fukuda4Hoa Tran Thi Nhu5Olga Stelmashenko6Flavia Letícia Martins Peçanha7Rayner Rodriguez-Diaz8Eric Bushong9Thomas Deerinck10Sebastien Phan11Yusuf Ali12Ingo Leibiger13Minni Chua14Thomas Boudier15Sang-Ho Song16Martin Graf17George J. Augustine18Mark H. Ellisman19Per-Olof Berggren20Lee Kong Chian School of Medicine, Nanyang Technological UniversityKarolinska Intitutet, The Rolf Luft Research Center for Diabetes and EndocrinologyKarolinska Intitutet, The Rolf Luft Research Center for Diabetes and EndocrinologyLee Kong Chian School of Medicine, Nanyang Technological UniversityMolecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical SchoolBioinformatics Institute (ASTAR) and Image and Pervasive Access Lab (IPAL)Lee Kong Chian School of Medicine, Nanyang Technological UniversityUniversidade Federal do Rio de Janeiro (UFRJ)Miller School of Medicine, University of MiamiNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoLee Kong Chian School of Medicine, Nanyang Technological UniversityKarolinska Intitutet, The Rolf Luft Research Center for Diabetes and EndocrinologyLee Kong Chian School of Medicine, Nanyang Technological UniversityBioinformatics Institute (ASTAR) and Image and Pervasive Access Lab (IPAL)Lee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityNational Center for Microscopy and Imaging Research (NCMIR), University of California San DiegoLee Kong Chian School of Medicine, Nanyang Technological UniversityPancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches.https://doi.org/10.1038/s41467-019-11517-x |
spellingShingle | Rafael Arrojo e Drigo Stefan Jacob Concha F. García-Prieto Xiaofeng Zheng Masahiro Fukuda Hoa Tran Thi Nhu Olga Stelmashenko Flavia Letícia Martins Peçanha Rayner Rodriguez-Diaz Eric Bushong Thomas Deerinck Sebastien Phan Yusuf Ali Ingo Leibiger Minni Chua Thomas Boudier Sang-Ho Song Martin Graf George J. Augustine Mark H. Ellisman Per-Olof Berggren Structural basis for delta cell paracrine regulation in pancreatic islets Nature Communications |
title | Structural basis for delta cell paracrine regulation in pancreatic islets |
title_full | Structural basis for delta cell paracrine regulation in pancreatic islets |
title_fullStr | Structural basis for delta cell paracrine regulation in pancreatic islets |
title_full_unstemmed | Structural basis for delta cell paracrine regulation in pancreatic islets |
title_short | Structural basis for delta cell paracrine regulation in pancreatic islets |
title_sort | structural basis for delta cell paracrine regulation in pancreatic islets |
url | https://doi.org/10.1038/s41467-019-11517-x |
work_keys_str_mv | AT rafaelarrojoedrigo structuralbasisfordeltacellparacrineregulationinpancreaticislets AT stefanjacob structuralbasisfordeltacellparacrineregulationinpancreaticislets AT conchafgarciaprieto structuralbasisfordeltacellparacrineregulationinpancreaticislets AT xiaofengzheng structuralbasisfordeltacellparacrineregulationinpancreaticislets AT masahirofukuda structuralbasisfordeltacellparacrineregulationinpancreaticislets AT hoatranthinhu structuralbasisfordeltacellparacrineregulationinpancreaticislets AT olgastelmashenko structuralbasisfordeltacellparacrineregulationinpancreaticislets AT flavialeticiamartinspecanha structuralbasisfordeltacellparacrineregulationinpancreaticislets AT raynerrodriguezdiaz structuralbasisfordeltacellparacrineregulationinpancreaticislets AT ericbushong structuralbasisfordeltacellparacrineregulationinpancreaticislets AT thomasdeerinck structuralbasisfordeltacellparacrineregulationinpancreaticislets AT sebastienphan structuralbasisfordeltacellparacrineregulationinpancreaticislets AT yusufali structuralbasisfordeltacellparacrineregulationinpancreaticislets AT ingoleibiger structuralbasisfordeltacellparacrineregulationinpancreaticislets AT minnichua structuralbasisfordeltacellparacrineregulationinpancreaticislets AT thomasboudier structuralbasisfordeltacellparacrineregulationinpancreaticislets AT sanghosong structuralbasisfordeltacellparacrineregulationinpancreaticislets AT martingraf structuralbasisfordeltacellparacrineregulationinpancreaticislets AT georgejaugustine structuralbasisfordeltacellparacrineregulationinpancreaticislets AT markhellisman structuralbasisfordeltacellparacrineregulationinpancreaticislets AT perolofberggren structuralbasisfordeltacellparacrineregulationinpancreaticislets |