Molecular Mechanism of Mutational Disruption of DCLK1 Autoinhibition Provides a Rationale for Inhibitor Screening

Molecular Mechanism of Mutational Disruption of DCLK1 Autoinhibition Provides a Rationale for Inhibitor Screening

Doublecortin-like kinase 1 (DCLK1) is a prominent kinase involved in carcinogenesis, serving as a diagnostic marker for early cancer detection and prevention, as well as a target for cancer therapy. Extensive research efforts have been dedicated to understanding its role in cancer development and de...

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Bibliographic Details
Main Authors:	Weizhi Chen, Rui Liu, Yamei Yu, Dongqing Wei, Qiang Chen, Qin Xu
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	International Journal of Molecular Sciences
Subjects:	DCLK1 cancer mutation autoinhibitory domain molecular dynamics simulation inhibitors screening
Online Access:	https://www.mdpi.com/1422-0067/24/18/14020

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