Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26
ABSTRACTThe recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1739565 |
| _version_ | 1797265848610586624 |
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| author | Naveen Vankadari Jacqueline A. Wilce |
| author_facet | Naveen Vankadari Jacqueline A. Wilce |
| author_sort | Naveen Vankadari |
| collection | DOAJ |
| description | ABSTRACTThe recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics. |
| first_indexed | 2024-03-07T17:24:54Z |
| format | Article |
| id | doaj.art-18bc516ea5594fdfb087ccda52423f84 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-25T00:51:19Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-18bc516ea5594fdfb087ccda52423f842024-03-11T16:04:22ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-019160160410.1080/22221751.2020.1739565Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26Naveen Vankadari0Jacqueline A. Wilce1Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, AustraliaMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, AustraliaABSTRACTThe recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics.https://www.tandfonline.com/doi/10.1080/22221751.2020.1739565CoronavirusCD26glycosylationDPP4spike glycoproteindocking |
| spellingShingle | Naveen Vankadari Jacqueline A. Wilce Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 Emerging Microbes and Infections Coronavirus CD26 glycosylation DPP4 spike glycoprotein docking |
| title | Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 |
| title_full | Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 |
| title_fullStr | Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 |
| title_full_unstemmed | Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 |
| title_short | Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 |
| title_sort | emerging covid 19 coronavirus glycan shield and structure prediction of spike glycoprotein and its interaction with human cd26 |
| topic | Coronavirus CD26 glycosylation DPP4 spike glycoprotein docking |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1739565 |
| work_keys_str_mv | AT naveenvankadari emergingcovid19coronavirusglycanshieldandstructurepredictionofspikeglycoproteinanditsinteractionwithhumancd26 AT jacquelineawilce emergingcovid19coronavirusglycanshieldandstructurepredictionofspikeglycoproteinanditsinteractionwithhumancd26 |