Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech Republic
Background: An epidemiological study conducted over four years revealed increased prevalence of neurodegenerative parkinsonism in a small, isolated region (10 villages, with a combined population of 8664, with approx. 2927 over 50 years of age) of south-eastern Moravia, Czech Republic. The aim of th...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Palacký University Olomouc, Faculty of Medicine and Dentistry
2016-03-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201601-0023_Familial_autosomal-dominant_neurodegenerative_parkinsonism_with_cognitive_deterioration_spanning_five_generati.php |
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| author | Katerina Mensikova Marek Godava Petr Kanovsky Pavel Otruba Michaela Kaiserova Miroslav Vastik Lenka Mikulicova Tereza Bartonikova Radek Vrtel Radek Vodicka Sandra Kurcova Petr Jugas Josef Ovecka Ludmila Sachova Frantisek Dvorsky |
| author_facet | Katerina Mensikova Marek Godava Petr Kanovsky Pavel Otruba Michaela Kaiserova Miroslav Vastik Lenka Mikulicova Tereza Bartonikova Radek Vrtel Radek Vodicka Sandra Kurcova Petr Jugas Josef Ovecka Ludmila Sachova Frantisek Dvorsky |
| author_sort | Katerina Mensikova |
| collection | DOAJ |
| description | Background: An epidemiological study conducted over four years revealed increased prevalence of neurodegenerative parkinsonism in a small, isolated region (10 villages, with a combined population of 8664, with approx. 2927 over 50 years of age) of south-eastern Moravia, Czech Republic. The aim of this study was to obtain more detailed information on the medical history of the relatives of individuals with confirmed parkinsonism in an isolated rural population in south-eastern Moravia, Czech Republic.
Methods: We did detailed genealogical research on the families of all inhabitants with confirmed parkinsonism and compiled the pedigrees. These were modified on the basis of information from a consecutive door-to-door survey and local municipal and church registers.
Results: In the first stage, three large pedigrees with a familial occurrence of parkinsonism were found; two originated in one of the region's villages. In the second stage, these two pedigrees were combined into one large family tree.
Conclusions: The high prevalence of parkinsonism in the researched area is caused by the familial aggregation of parkinsonism that was found in two large family trees. This is probably the result of the genetic isolation of the regional population due to the very low migration rate of its inhabitants to neighboring regions in the last two centuries. |
| first_indexed | 2024-12-13T11:40:46Z |
| format | Article |
| id | doaj.art-18bc6b39476c45b2acc8b29d79471ca6 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-13T11:40:46Z |
| publishDate | 2016-03-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-18bc6b39476c45b2acc8b29d79471ca62022-12-21T23:47:39ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212016-03-01160115816010.5507/bp.2015.013bio-201601-0023Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech RepublicKaterina Mensikova0Marek Godava1Petr Kanovsky2Pavel Otruba3Michaela Kaiserova4Miroslav Vastik5Lenka Mikulicova6Tereza Bartonikova7Radek Vrtel8Radek Vodicka9Sandra Kurcova10Petr Jugas11Josef Ovecka12Ludmila Sachova13Frantisek Dvorsky14Department of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Medical Genetics and Fetal Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Medical Genetics and Fetal Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Medical Genetics and Fetal Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicNeurology Outpatient Clinic, Veseli nad Moravou, Czech RepublicGeneral Practitioner, Lipov, Czech RepublicGeneral Practicioner, Velka nad Velickou-Javornik, Czech RepublicGeneral Practicioner, Velka nad Velickou-Javornik, Czech RepublicBackground: An epidemiological study conducted over four years revealed increased prevalence of neurodegenerative parkinsonism in a small, isolated region (10 villages, with a combined population of 8664, with approx. 2927 over 50 years of age) of south-eastern Moravia, Czech Republic. The aim of this study was to obtain more detailed information on the medical history of the relatives of individuals with confirmed parkinsonism in an isolated rural population in south-eastern Moravia, Czech Republic. Methods: We did detailed genealogical research on the families of all inhabitants with confirmed parkinsonism and compiled the pedigrees. These were modified on the basis of information from a consecutive door-to-door survey and local municipal and church registers. Results: In the first stage, three large pedigrees with a familial occurrence of parkinsonism were found; two originated in one of the region's villages. In the second stage, these two pedigrees were combined into one large family tree. Conclusions: The high prevalence of parkinsonism in the researched area is caused by the familial aggregation of parkinsonism that was found in two large family trees. This is probably the result of the genetic isolation of the regional population due to the very low migration rate of its inhabitants to neighboring regions in the last two centuries.https://biomed.papers.upol.cz/artkey/bio-201601-0023_Familial_autosomal-dominant_neurodegenerative_parkinsonism_with_cognitive_deterioration_spanning_five_generati.phpparkinsonismcognitive deteriorationisolated populationneuroepidemiologygenealogy |
| spellingShingle | Katerina Mensikova Marek Godava Petr Kanovsky Pavel Otruba Michaela Kaiserova Miroslav Vastik Lenka Mikulicova Tereza Bartonikova Radek Vrtel Radek Vodicka Sandra Kurcova Petr Jugas Josef Ovecka Ludmila Sachova Frantisek Dvorsky Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech Republic Biomedical Papers parkinsonism cognitive deterioration isolated population neuroepidemiology genealogy |
| title | Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech Republic |
| title_full | Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech Republic |
| title_fullStr | Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech Republic |
| title_full_unstemmed | Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech Republic |
| title_short | Familial, autosomal-dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south-eastern Moravia, Czech Republic |
| title_sort | familial autosomal dominant neurodegenerative parkinsonism with cognitive deterioration spanning five generations in a genetically isolated population of south eastern moravia czech republic |
| topic | parkinsonism cognitive deterioration isolated population neuroepidemiology genealogy |
| url | https://biomed.papers.upol.cz/artkey/bio-201601-0023_Familial_autosomal-dominant_neurodegenerative_parkinsonism_with_cognitive_deterioration_spanning_five_generati.php |
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