NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice
A mitochondrial tRNA modification enzyme, NSUN3, is found to be essential for embryonic development in mice, with whole-body knockout causing embryonic lethality and heart-specific Nsun3 knockout leading to heart aberration in older mice.
Bibliographic Details
| Main Authors: |
Yoshitaka Murakami,
Fan-Yan Wei,
Yoshimi Kawamura,
Haruki Horiguchi,
Tsuyoshi Kadomatsu,
Keishi Miyata,
Kyoko Miura,
Yuichi Oike,
Yukio Ando,
Mitsuharu Ueda,
Kazuhito Tomizawa,
Takeshi Chujo |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2023-03-01
|
|---|
| Series: | Communications Biology
|
|---|
| Online Access: | https://doi.org/10.1038/s42003-023-04680-x
|
|---|