National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso
Abstract Malaria due to the Plasmodium falciparum parasite remains a threat to human health despite eradication efforts and the development of anti-malarial treatments, such as artemisinin combination therapies. Human movement and migration have been linked to the propagation of malaria on national...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26878-5 |
| _version_ | 1828069612358467584 |
|---|---|
| author | Robert J. Zupko Tran Dang Nguyen Amy Wesolowski Jaline Gerardin Maciej F. Boni |
| author_facet | Robert J. Zupko Tran Dang Nguyen Amy Wesolowski Jaline Gerardin Maciej F. Boni |
| author_sort | Robert J. Zupko |
| collection | DOAJ |
| description | Abstract Malaria due to the Plasmodium falciparum parasite remains a threat to human health despite eradication efforts and the development of anti-malarial treatments, such as artemisinin combination therapies. Human movement and migration have been linked to the propagation of malaria on national scales, highlighting the need for the incorporation of human movement in modeling efforts. Spatially couped individual-based models have been used to study how anti-malarial resistance evolves and spreads in response to drug policy changes; however, as the spatial scale of the model increases, the challenges associated with modeling of movement also increase. In this paper we discuss the development, calibration, and validation of a movement model in the context of a national-scale, spatial, individual-based model used to study the evolution of drug resistance in the malaria parasite. |
| first_indexed | 2024-04-11T00:22:35Z |
| format | Article |
| id | doaj.art-18c1da1da6fb4847bccf3a1323895a22 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T00:22:35Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-18c1da1da6fb4847bccf3a1323895a222023-01-08T12:09:34ZengNature PortfolioScientific Reports2045-23222023-01-011311810.1038/s41598-022-26878-5National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina FasoRobert J. Zupko0Tran Dang Nguyen1Amy Wesolowski2Jaline Gerardin3Maciej F. Boni4Center for Infectious Disease Dynamics, Pennsylvania State UniversityCenter for Infectious Disease Dynamics, Pennsylvania State UniversityDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthDepartment of Preventive Medicine and Institute for Global Health, Northwestern UniversityCenter for Infectious Disease Dynamics, Pennsylvania State UniversityAbstract Malaria due to the Plasmodium falciparum parasite remains a threat to human health despite eradication efforts and the development of anti-malarial treatments, such as artemisinin combination therapies. Human movement and migration have been linked to the propagation of malaria on national scales, highlighting the need for the incorporation of human movement in modeling efforts. Spatially couped individual-based models have been used to study how anti-malarial resistance evolves and spreads in response to drug policy changes; however, as the spatial scale of the model increases, the challenges associated with modeling of movement also increase. In this paper we discuss the development, calibration, and validation of a movement model in the context of a national-scale, spatial, individual-based model used to study the evolution of drug resistance in the malaria parasite.https://doi.org/10.1038/s41598-022-26878-5 |
| spellingShingle | Robert J. Zupko Tran Dang Nguyen Amy Wesolowski Jaline Gerardin Maciej F. Boni National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso Scientific Reports |
| title | National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso |
| title_full | National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso |
| title_fullStr | National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso |
| title_full_unstemmed | National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso |
| title_short | National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso |
| title_sort | national scale simulation of human movement in a spatially coupled individual based model of malaria in burkina faso |
| url | https://doi.org/10.1038/s41598-022-26878-5 |
| work_keys_str_mv | AT robertjzupko nationalscalesimulationofhumanmovementinaspatiallycoupledindividualbasedmodelofmalariainburkinafaso AT trandangnguyen nationalscalesimulationofhumanmovementinaspatiallycoupledindividualbasedmodelofmalariainburkinafaso AT amywesolowski nationalscalesimulationofhumanmovementinaspatiallycoupledindividualbasedmodelofmalariainburkinafaso AT jalinegerardin nationalscalesimulationofhumanmovementinaspatiallycoupledindividualbasedmodelofmalariainburkinafaso AT maciejfboni nationalscalesimulationofhumanmovementinaspatiallycoupledindividualbasedmodelofmalariainburkinafaso |