Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans
Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction. Serum levels of selenoprotein P are elevated during aging and in people with type 2 diabetes, non-alcoholic fatty liver disease,...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.633703/full |
| _version_ | 1818911368537964544 |
|---|---|
| author | Yuki Isobe Hiroki Asakura Hiromasa Tsujiguchi Takayuki Kannon Hiroaki Takayama Yumie Takeshita Kiyo-aki Ishii Takehiro Kanamori Akinori Hara Tatsuya Yamashita Atsushi Tajima Shuichi Kaneko Hiroyuki Nakamura Toshinari Takamura |
| author_facet | Yuki Isobe Hiroki Asakura Hiromasa Tsujiguchi Takayuki Kannon Hiroaki Takayama Yumie Takeshita Kiyo-aki Ishii Takehiro Kanamori Akinori Hara Tatsuya Yamashita Atsushi Tajima Shuichi Kaneko Hiroyuki Nakamura Toshinari Takamura |
| author_sort | Yuki Isobe |
| collection | DOAJ |
| description | Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction. Serum levels of selenoprotein P are elevated during aging and in people with type 2 diabetes, non-alcoholic fatty liver disease, and hepatitis C. However, how serum levels of full-length selenoprotein P are regulated largely remains unknown, especially in the general population. To understand the significance of serum selenoprotein P levels in the general population, we evaluated intrinsic and environmental factors associated with serum levels of full-length selenoprotein P in 1,183 subjects participating in the Shika-health checkup cohort. Serum levels of selenium were positively correlated with liver enzymes and alcohol intake and negatively correlated with body mass index. Serum levels of selenoprotein P were positively correlated with age, liver enzymes, and alcohol intake. In multiple regression analyses, alcohol intake was positively correlated with serum levels of both selenium and selenoprotein P independently of age, gender, liver enzymes, and fatty liver on ultrasonography. In conclusion, alcohol intake is associated with elevated serum levels of selenium and selenoprotein P independently of liver enzyme levels and liver fat in the general population. Moderate alcohol intake may exert beneficial or harmful effects on health, at least partly by upregulating selenoprotein P. These findings increase our understanding of alcohol-mediated redox regulation and form the basis for the adoption of appropriate drinking guidelines. |
| first_indexed | 2024-12-19T22:57:35Z |
| format | Article |
| id | doaj.art-18c28b5a8a1f42cca014c8cc1b1d9b5e |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-19T22:57:35Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-18c28b5a8a1f42cca014c8cc1b1d9b5e2022-12-21T20:02:36ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-02-01810.3389/fnut.2021.633703633703Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in HumansYuki Isobe0Hiroki Asakura1Hiromasa Tsujiguchi2Takayuki Kannon3Hiroaki Takayama4Yumie Takeshita5Kiyo-aki Ishii6Takehiro Kanamori7Akinori Hara8Tatsuya Yamashita9Atsushi Tajima10Shuichi Kaneko11Hiroyuki Nakamura12Toshinari Takamura13Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Bioinformatics and Genomics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Bioinformatics and Genomics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanSelenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction. Serum levels of selenoprotein P are elevated during aging and in people with type 2 diabetes, non-alcoholic fatty liver disease, and hepatitis C. However, how serum levels of full-length selenoprotein P are regulated largely remains unknown, especially in the general population. To understand the significance of serum selenoprotein P levels in the general population, we evaluated intrinsic and environmental factors associated with serum levels of full-length selenoprotein P in 1,183 subjects participating in the Shika-health checkup cohort. Serum levels of selenium were positively correlated with liver enzymes and alcohol intake and negatively correlated with body mass index. Serum levels of selenoprotein P were positively correlated with age, liver enzymes, and alcohol intake. In multiple regression analyses, alcohol intake was positively correlated with serum levels of both selenium and selenoprotein P independently of age, gender, liver enzymes, and fatty liver on ultrasonography. In conclusion, alcohol intake is associated with elevated serum levels of selenium and selenoprotein P independently of liver enzyme levels and liver fat in the general population. Moderate alcohol intake may exert beneficial or harmful effects on health, at least partly by upregulating selenoprotein P. These findings increase our understanding of alcohol-mediated redox regulation and form the basis for the adoption of appropriate drinking guidelines.https://www.frontiersin.org/articles/10.3389/fnut.2021.633703/fullalcoholseleniumselenoprotein Pdiabetesfatty liverhepatokine |
| spellingShingle | Yuki Isobe Hiroki Asakura Hiromasa Tsujiguchi Takayuki Kannon Hiroaki Takayama Yumie Takeshita Kiyo-aki Ishii Takehiro Kanamori Akinori Hara Tatsuya Yamashita Atsushi Tajima Shuichi Kaneko Hiroyuki Nakamura Toshinari Takamura Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans Frontiers in Nutrition alcohol selenium selenoprotein P diabetes fatty liver hepatokine |
| title | Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans |
| title_full | Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans |
| title_fullStr | Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans |
| title_full_unstemmed | Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans |
| title_short | Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans |
| title_sort | alcohol intake is associated with elevated serum levels of selenium and selenoprotein p in humans |
| topic | alcohol selenium selenoprotein P diabetes fatty liver hepatokine |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.633703/full |
| work_keys_str_mv | AT yukiisobe alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT hirokiasakura alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT hiromasatsujiguchi alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT takayukikannon alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT hiroakitakayama alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT yumietakeshita alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT kiyoakiishii alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT takehirokanamori alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT akinorihara alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT tatsuyayamashita alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT atsushitajima alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT shuichikaneko alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT hiroyukinakamura alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans AT toshinaritakamura alcoholintakeisassociatedwithelevatedserumlevelsofseleniumandselenoproteinpinhumans |