Compartments and Connections Within the Germinal Center
Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. I...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.659151/full |
| _version_ | 1818451499311693824 |
|---|---|
| author | Domenick E. Kennedy Marcus R. Clark |
| author_facet | Domenick E. Kennedy Marcus R. Clark |
| author_sort | Domenick E. Kennedy |
| collection | DOAJ |
| description | Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases. |
| first_indexed | 2024-12-14T21:08:10Z |
| format | Article |
| id | doaj.art-18c37b345bdf44469ccadb913bc84edd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T21:08:10Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-18c37b345bdf44469ccadb913bc84edd2022-12-21T22:47:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.659151659151Compartments and Connections Within the Germinal CenterDomenick E. KennedyMarcus R. ClarkProtective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2021.659151/fullB cellgerminal centertranscriptionepigeneticsT cell helptingible body macrophage |
| spellingShingle | Domenick E. Kennedy Marcus R. Clark Compartments and Connections Within the Germinal Center Frontiers in Immunology B cell germinal center transcription epigenetics T cell help tingible body macrophage |
| title | Compartments and Connections Within the Germinal Center |
| title_full | Compartments and Connections Within the Germinal Center |
| title_fullStr | Compartments and Connections Within the Germinal Center |
| title_full_unstemmed | Compartments and Connections Within the Germinal Center |
| title_short | Compartments and Connections Within the Germinal Center |
| title_sort | compartments and connections within the germinal center |
| topic | B cell germinal center transcription epigenetics T cell help tingible body macrophage |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.659151/full |
| work_keys_str_mv | AT domenickekennedy compartmentsandconnectionswithinthegerminalcenter AT marcusrclark compartmentsandconnectionswithinthegerminalcenter |