Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus
Objective To investigate the effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with type 2 diabetes mellitus. Methods A total of 100 patients scheduled to undergo spinal surgery were recruited. Among them, 65 patients with diabetes mellitus were rand...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2022-04-01
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| Series: | Xin yixue |
| Subjects: | |
| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1652688639269-648869919.pdf |
| _version_ | 1811311210329538560 |
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| author | Guo Ruimin, Fan Junbai |
| author_facet | Guo Ruimin, Fan Junbai |
| author_sort | Guo Ruimin, Fan Junbai |
| collection | DOAJ |
| description | Objective To investigate the effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with type 2 diabetes mellitus. Methods A total of 100 patients scheduled to undergo spinal surgery were recruited. Among them, 65 patients with diabetes mellitus were randomly divided into the pretreatment group （n = 32） and blank control group （n = 33）. In the pretreatment group, patients were pretreated with flurbiprofen axetil injection at a dose of 1.0 mg/kg at 10 min before anesthesia induction, and those in the blank control group received routine anesthesia without pretreatment. Non-diabetic patients were assigned into the normal control group （n = 35）, who were not given with pretreatment. The changes of the serum levels of Apelin-13, Ang Ⅱ, MDA, IL-6, blood glucose were observed at preoperative （T0）, intraoperative 1 h （T1） and postoperative 1 h （T2） time points, respectively. Meantime, the white blood cell count （WBC）and neutrophil percentage（NEUT%） were compared before and 1 d after operation. Results The serum levels of Ang Ⅱ, MDA and IL-6 in all three groups showed a trend of initial increase （T0-T1） and then decline （T1-T2）, and the levels at T2 were higher than those at T0. However, the serum levels of Apelin-13 were initially decreased and then increased, and the levels at T2 were significantly lower compared with those at T0 （all P < 0.05）. Compared with the normal control group, all serum indexes at the same time point were increased, blood glucose fluctuation was enlarged, and postoperative WBC and NEUT% were increased in the pretreatment and blank control groups. Compared with the blank control group, the serum level of Apelin-13 was significantly up-regulated, those of IL-6, MDA and Ang Ⅱ were significantly decreased, and postoperative WBC, NEUT% and blood glucose fluctuation were significantly decreased in the pretreatment group （all P < 0.05）. Conclusion Flurbiprofen axetil preconditioning can regulate the serum level of Apelin-13, lower inflammatory factors and oxidative stress indexes to certain extent, inhibit the increase of WBC and NEUT% after operation, and mitigate perioperative oxidative stress and blood glucose fluctuation in diabetic patients. |
| first_indexed | 2024-04-13T10:13:44Z |
| format | Article |
| id | doaj.art-18c71eb3e6cc4feeaa75829eb6167890 |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-13T10:13:44Z |
| publishDate | 2022-04-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-18c71eb3e6cc4feeaa75829eb61678902022-12-22T02:50:48ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-04-0153425425910.3969/j.issn.0253-9802.2022.04.006Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitusGuo Ruimin, Fan Junbai0△Department of Anesthesiology, Shanxi Medical University, Taiyuan 030001, ChinaObjective To investigate the effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with type 2 diabetes mellitus. Methods A total of 100 patients scheduled to undergo spinal surgery were recruited. Among them, 65 patients with diabetes mellitus were randomly divided into the pretreatment group （n = 32） and blank control group （n = 33）. In the pretreatment group, patients were pretreated with flurbiprofen axetil injection at a dose of 1.0 mg/kg at 10 min before anesthesia induction, and those in the blank control group received routine anesthesia without pretreatment. Non-diabetic patients were assigned into the normal control group （n = 35）, who were not given with pretreatment. The changes of the serum levels of Apelin-13, Ang Ⅱ, MDA, IL-6, blood glucose were observed at preoperative （T0）, intraoperative 1 h （T1） and postoperative 1 h （T2） time points, respectively. Meantime, the white blood cell count （WBC）and neutrophil percentage（NEUT%） were compared before and 1 d after operation. Results The serum levels of Ang Ⅱ, MDA and IL-6 in all three groups showed a trend of initial increase （T0-T1） and then decline （T1-T2）, and the levels at T2 were higher than those at T0. However, the serum levels of Apelin-13 were initially decreased and then increased, and the levels at T2 were significantly lower compared with those at T0 （all P < 0.05）. Compared with the normal control group, all serum indexes at the same time point were increased, blood glucose fluctuation was enlarged, and postoperative WBC and NEUT% were increased in the pretreatment and blank control groups. Compared with the blank control group, the serum level of Apelin-13 was significantly up-regulated, those of IL-6, MDA and Ang Ⅱ were significantly decreased, and postoperative WBC, NEUT% and blood glucose fluctuation were significantly decreased in the pretreatment group （all P < 0.05）. Conclusion Flurbiprofen axetil preconditioning can regulate the serum level of Apelin-13, lower inflammatory factors and oxidative stress indexes to certain extent, inhibit the increase of WBC and NEUT% after operation, and mitigate perioperative oxidative stress and blood glucose fluctuation in diabetic patients.https://www.xinyixue.cn/fileup/0253-9802/PDF/1652688639269-648869919.pdf|type 2 diabetes mellitus|oxidative stress|inflammation|apelin|flurbiprofen axetil |
| spellingShingle | Guo Ruimin, Fan Junbai Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus Xin yixue |type 2 diabetes mellitus|oxidative stress|inflammation|apelin|flurbiprofen axetil |
| title | Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus |
| title_full | Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus |
| title_fullStr | Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus |
| title_full_unstemmed | Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus |
| title_short | Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus |
| title_sort | effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and apelin in patients with diabetes mellitus |
| topic | |type 2 diabetes mellitus|oxidative stress|inflammation|apelin|flurbiprofen axetil |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1652688639269-648869919.pdf |
| work_keys_str_mv | AT guoruiminfanjunbai effectofflurbiprofenaxetilpretreatmentonperioperativeoxidativestressandapelininpatientswithdiabetesmellitus |