Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations
Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-02-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/2/142 |
| _version_ | 1811307802537230336 |
|---|---|
| author | Nermin E. Eleraky Ayat Allam Sahar B. Hassan Mahmoud M. Omar |
| author_facet | Nermin E. Eleraky Ayat Allam Sahar B. Hassan Mahmoud M. Omar |
| author_sort | Nermin E. Eleraky |
| collection | DOAJ |
| description | Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application. |
| first_indexed | 2024-04-13T09:10:48Z |
| format | Article |
| id | doaj.art-18c77d38709442ccaf7fad7a5c119ee6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T09:10:48Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-18c77d38709442ccaf7fad7a5c119ee62022-12-22T02:52:53ZengMDPI AGPharmaceutics1999-49232020-02-0112214210.3390/pharmaceutics12020142pharmaceutics12020142Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical InnovationsNermin E. Eleraky0Ayat Allam1Sahar B. Hassan2Mahmoud M. Omar3Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, EgyptDepartment of Clinical pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Deraya University, Minia 61768, EgyptBased on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application.https://www.mdpi.com/1999-4923/12/2/142nanomedicineantibacterial resistanceinhibition of antibacterial resistanceanti-biofilm mechanismsorganic nanosystemsinorganic nanosystems |
| spellingShingle | Nermin E. Eleraky Ayat Allam Sahar B. Hassan Mahmoud M. Omar Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations Pharmaceutics nanomedicine antibacterial resistance inhibition of antibacterial resistance anti-biofilm mechanisms organic nanosystems inorganic nanosystems |
| title | Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations |
| title_full | Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations |
| title_fullStr | Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations |
| title_full_unstemmed | Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations |
| title_short | Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations |
| title_sort | nanomedicine fight against antibacterial resistance an overview of the recent pharmaceutical innovations |
| topic | nanomedicine antibacterial resistance inhibition of antibacterial resistance anti-biofilm mechanisms organic nanosystems inorganic nanosystems |
| url | https://www.mdpi.com/1999-4923/12/2/142 |
| work_keys_str_mv | AT nermineeleraky nanomedicinefightagainstantibacterialresistanceanoverviewoftherecentpharmaceuticalinnovations AT ayatallam nanomedicinefightagainstantibacterialresistanceanoverviewoftherecentpharmaceuticalinnovations AT saharbhassan nanomedicinefightagainstantibacterialresistanceanoverviewoftherecentpharmaceuticalinnovations AT mahmoudmomar nanomedicinefightagainstantibacterialresistanceanoverviewoftherecentpharmaceuticalinnovations |