Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy
Acute posterior syphilitic placoid chorioretinopathy (ASPPC) is a rare ocular manifestation of syphilis characterized by outer retinal layers involvement and drop in visual acuity. The current work documents outer retinal layer involvement in this pathology and their reconstitution with treatment by...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/12/9/1361 |
| _version_ | 1797485734461964288 |
|---|---|
| author | Fabrizio Giansanti Stefano Mercuri Lorenzo Vannozzi Andrea Govetto Angelo Maria Minnella Tomaso Caporossi Alfonso Savastano Maria Cristina Savastano Gloria Gambini Stanislao Rizzo Gianni Virgili Daniela Bacherini |
| author_facet | Fabrizio Giansanti Stefano Mercuri Lorenzo Vannozzi Andrea Govetto Angelo Maria Minnella Tomaso Caporossi Alfonso Savastano Maria Cristina Savastano Gloria Gambini Stanislao Rizzo Gianni Virgili Daniela Bacherini |
| author_sort | Fabrizio Giansanti |
| collection | DOAJ |
| description | Acute posterior syphilitic placoid chorioretinopathy (ASPPC) is a rare ocular manifestation of syphilis characterized by outer retinal layers involvement and drop in visual acuity. The current work documents outer retinal layer involvement in this pathology and their reconstitution with treatment by means of adaptive optics (AO). Three eyes of two patients together with four controls eyes were included in the study. Patients underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan centered on fovea, where vessel density (VD) and vessel perfusion (VP) were calculated. AO images centered on fovea were acquired and cone density (CD) and cone spacing (CS) were measured and compared to control group. Multimodal imaging was performed at presentation, at 10 days, and at 2-month follow-up. All eyes improved in visual acuity, with reconstitution in outer retinal layers at 2-month follow-up. Overall choriocapillary layer VD and VP improved. AO imaging was able to identify outer retinal alterations at presentation and at follow-ups, with improvement in tissue architecture. CD and CS was respectively lower and greater than controls at all follow-ups and improved within patients at the 2-month follow-up. In conclusion, AO was able to document outer retinal alterations in ASPPC at presentation and improvement over the follow-up, representing a tool to study photoreceptor layer involvement in this pathology. |
| first_indexed | 2024-03-09T23:23:07Z |
| format | Article |
| id | doaj.art-18c7fdffcfee4071b449d406fede95b5 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T23:23:07Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-18c7fdffcfee4071b449d406fede95b52023-11-23T17:22:46ZengMDPI AGLife2075-17292022-08-01129136110.3390/life12091361Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid ChorioretinopathyFabrizio Giansanti0Stefano Mercuri1Lorenzo Vannozzi2Andrea Govetto3Angelo Maria Minnella4Tomaso Caporossi5Alfonso Savastano6Maria Cristina Savastano7Gloria Gambini8Stanislao Rizzo9Gianni Virgili10Daniela Bacherini11Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, ItalyDepartment of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, ItalyDepartment of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, ItalyOphthalmology Department, Asst-Settelaghi, University of Insubria, 21100 Varese, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, ItalyDepartment of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, ItalyDepartment of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, ItalyAcute posterior syphilitic placoid chorioretinopathy (ASPPC) is a rare ocular manifestation of syphilis characterized by outer retinal layers involvement and drop in visual acuity. The current work documents outer retinal layer involvement in this pathology and their reconstitution with treatment by means of adaptive optics (AO). Three eyes of two patients together with four controls eyes were included in the study. Patients underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan centered on fovea, where vessel density (VD) and vessel perfusion (VP) were calculated. AO images centered on fovea were acquired and cone density (CD) and cone spacing (CS) were measured and compared to control group. Multimodal imaging was performed at presentation, at 10 days, and at 2-month follow-up. All eyes improved in visual acuity, with reconstitution in outer retinal layers at 2-month follow-up. Overall choriocapillary layer VD and VP improved. AO imaging was able to identify outer retinal alterations at presentation and at follow-ups, with improvement in tissue architecture. CD and CS was respectively lower and greater than controls at all follow-ups and improved within patients at the 2-month follow-up. In conclusion, AO was able to document outer retinal alterations in ASPPC at presentation and improvement over the follow-up, representing a tool to study photoreceptor layer involvement in this pathology.https://www.mdpi.com/2075-1729/12/9/1361acute syphilitic posterior placoid chorioretinopathyadaptive opticsoptical coherence tomographyoptical coherence tomography angiographysyphilisuveitis |
| spellingShingle | Fabrizio Giansanti Stefano Mercuri Lorenzo Vannozzi Andrea Govetto Angelo Maria Minnella Tomaso Caporossi Alfonso Savastano Maria Cristina Savastano Gloria Gambini Stanislao Rizzo Gianni Virgili Daniela Bacherini Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy Life acute syphilitic posterior placoid chorioretinopathy adaptive optics optical coherence tomography optical coherence tomography angiography syphilis uveitis |
| title | Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy |
| title_full | Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy |
| title_fullStr | Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy |
| title_full_unstemmed | Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy |
| title_short | Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy |
| title_sort | adaptive optics imaging to analyze the photoreceptor layer reconstitution in acute syphilitic posterior placoid chorioretinopathy |
| topic | acute syphilitic posterior placoid chorioretinopathy adaptive optics optical coherence tomography optical coherence tomography angiography syphilis uveitis |
| url | https://www.mdpi.com/2075-1729/12/9/1361 |
| work_keys_str_mv | AT fabriziogiansanti adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT stefanomercuri adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT lorenzovannozzi adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT andreagovetto adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT angelomariaminnella adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT tomasocaporossi adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT alfonsosavastano adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT mariacristinasavastano adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT gloriagambini adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT stanislaorizzo adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT giannivirgili adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy AT danielabacherini adaptiveopticsimagingtoanalyzethephotoreceptorlayerreconstitutioninacutesyphiliticposteriorplacoidchorioretinopathy |