Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol
Aim. Modern medicine widely applies drugs from the group of 1,2,4-triazole (fluconazole, triazolam, alprazolam, letrozole and others) in the practice. This class of compounds has synthetic origin and a broad spectrum of biological activity, and is characterized by low toxicity. It is known that the...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2015-08-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| Subjects: | |
| Online Access: | http://pharmed.zsmu.edu.ua/article/view/45154/43760 |
| _version_ | 1811279891810746368 |
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| author | I. I. Aksionova O. I. Panasenko E. G. Knysh |
| author_facet | I. I. Aksionova O. I. Panasenko E. G. Knysh |
| author_sort | I. I. Aksionova |
| collection | DOAJ |
| description | Aim. Modern medicine widely applies drugs from the group of 1,2,4-triazole (fluconazole, triazolam, alprazolam, letrozole and others) in the practice. This class of compounds has synthetic origin and a broad spectrum of biological activity, and is characterized by low toxicity. It is known that the presence of triazole ring in the molecule effects on the range and intensity of biological action.
Methods and results. In order to create new biologically active compounds in a series of ylidene derivatives of 4-amino-5-(4-tretbutilfenil)-4H-1,2,4-triazole-3-thiol proposed preparative methods of synthesis 5-(4-tretbutilfenil) -4-R-4H-1,2,4-triazole-3-thiols have been proposed. The structure of synthesized compounds has been confirmed by 1H NMR-spectroscopy, chromatography-mass spectrometry and elemental analysis.
Conclusion. This indicates the possibility of using these substances to further biological studies. |
| first_indexed | 2024-04-13T01:03:59Z |
| format | Article |
| id | doaj.art-18c9cb2a953348349bf1a052126f8a9c |
| institution | Directory Open Access Journal |
| issn | 2306-8094 2409-2932 |
| language | English |
| last_indexed | 2024-04-13T01:03:59Z |
| publishDate | 2015-08-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj.art-18c9cb2a953348349bf1a052126f8a9c2022-12-22T03:09:23ZengZaporozhye State Medical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322015-08-012172010.14739/2409-2932.2015.2.45154Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiolI. I. AksionovaO. I. PanasenkoE. G. KnyshAim. Modern medicine widely applies drugs from the group of 1,2,4-triazole (fluconazole, triazolam, alprazolam, letrozole and others) in the practice. This class of compounds has synthetic origin and a broad spectrum of biological activity, and is characterized by low toxicity. It is known that the presence of triazole ring in the molecule effects on the range and intensity of biological action. Methods and results. In order to create new biologically active compounds in a series of ylidene derivatives of 4-amino-5-(4-tretbutilfenil)-4H-1,2,4-triazole-3-thiol proposed preparative methods of synthesis 5-(4-tretbutilfenil) -4-R-4H-1,2,4-triazole-3-thiols have been proposed. The structure of synthesized compounds has been confirmed by 1H NMR-spectroscopy, chromatography-mass spectrometry and elemental analysis. Conclusion. This indicates the possibility of using these substances to further biological studies.http://pharmed.zsmu.edu.ua/article/view/45154/43760Organic SynthesisYlidene DerivativesAminotriazoles1 2 4-triazoles |
| spellingShingle | I. I. Aksionova O. I. Panasenko E. G. Knysh Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Organic Synthesis Ylidene Derivatives Aminotriazoles 1 2 4-triazoles |
| title | Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol |
| title_full | Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol |
| title_fullStr | Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol |
| title_full_unstemmed | Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol |
| title_short | Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol |
| title_sort | synthesis of ylidene derivatives of 4 amino 5 4 tert butylphenyl 4h 1 2 4 triazole 3 thiol |
| topic | Organic Synthesis Ylidene Derivatives Aminotriazoles 1 2 4-triazoles |
| url | http://pharmed.zsmu.edu.ua/article/view/45154/43760 |
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