Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production
Abstract Background Fluralaner is a potent insecticide and acaricide with rapid and persistent efficacy. This study measured the efficacy of fluralaner flavored chews (Bravecto®, Merck Animal Health) administered to dogs against adult Ctenocephalides felis felis and egg production. Methods Twelve pu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2015-07-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-015-0965-4 |
| _version_ | 1827933745704861696 |
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| author | Michael W Dryden Vicki Smith Tashina Bennett Lisa Math James Kallman Kathleen Heaney Fangshi Sun |
| author_facet | Michael W Dryden Vicki Smith Tashina Bennett Lisa Math James Kallman Kathleen Heaney Fangshi Sun |
| author_sort | Michael W Dryden |
| collection | DOAJ |
| description | Abstract Background Fluralaner is a potent insecticide and acaricide with rapid and persistent efficacy. This study measured the efficacy of fluralaner flavored chews (Bravecto®, Merck Animal Health) administered to dogs against adult Ctenocephalides felis felis and egg production. Methods Twelve purpose-bred dogs were randomly allocated to two groups of six dogs each. Dogs in treatment group 1 were administered a single fluralaner flavored chew to achieve a minimum dose of at least 25 mg/kg while treatment group 2 served as untreated controls. On Days −2, 28, 56, 84, 91, 98, 105, 112, and 120 post-treatment, each dog was infested with approximately 200 unfed cat fleas, C. felis felis (KS1 strain). Forty-eight hours after treatment and 48 h after each infestation, eggs were collected over a 3-h period, counted and viability determined. Dogs were combed to remove any remaining fleas. Results Treatment of dogs with oral fluralaner provided a 100 % reduction in flea counts 48 h after treatment and within 48 h of every post-treatment infestation through Day122. Egg production from fluralaner treated dogs was reduced by 99.9 % (two eggs from one dog) within 48 h after treatment and not a single egg (100 % efficacy) was thereafter collected from treated dogs. Adult flea counts and egg production from the fluralaner-treated dogs were significantly lower than for non-treated controls at all post-treatment evaluations (P < 0.001). The two eggs collected from the single treated dog 48 h after treatment did not produce any adult fleas. As no additional eggs were collected from treated dogs, no viability assessment was performed. Conclusions A single oral dose of fluralaner flavored chews provided 100 % efficacy against repeated flea infestations on dogs for 4 months. Fluralaner reduced egg production of activity reproducing female fleas by 99.9 % and then killed every single female flea before any eggs could be produced following each subsequent re-infestation for the entire 122-day evaluation period. |
| first_indexed | 2024-03-13T07:29:07Z |
| format | Article |
| id | doaj.art-18c9f796142a45509c553d4b04f33cdc |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-03-13T07:29:07Z |
| publishDate | 2015-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-18c9f796142a45509c553d4b04f33cdc2023-06-04T11:09:55ZengBMCParasites & Vectors1756-33052015-07-01811710.1186/s13071-015-0965-4Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg productionMichael W Dryden0Vicki Smith1Tashina Bennett2Lisa Math3James Kallman4Kathleen Heaney5Fangshi Sun6Dept. of Diagnostic Medicine/Pathobiology, Kansas State UniversityDept. of Diagnostic Medicine/Pathobiology, Kansas State UniversityDept. of Diagnostic Medicine/Pathobiology, Kansas State UniversityMerck Animal Health, 2 Giralda FarmsMerck Animal Health, 2 Giralda FarmsMerck Animal Health, 2 Giralda FarmsMerck Animal Health, 2 Giralda FarmsAbstract Background Fluralaner is a potent insecticide and acaricide with rapid and persistent efficacy. This study measured the efficacy of fluralaner flavored chews (Bravecto®, Merck Animal Health) administered to dogs against adult Ctenocephalides felis felis and egg production. Methods Twelve purpose-bred dogs were randomly allocated to two groups of six dogs each. Dogs in treatment group 1 were administered a single fluralaner flavored chew to achieve a minimum dose of at least 25 mg/kg while treatment group 2 served as untreated controls. On Days −2, 28, 56, 84, 91, 98, 105, 112, and 120 post-treatment, each dog was infested with approximately 200 unfed cat fleas, C. felis felis (KS1 strain). Forty-eight hours after treatment and 48 h after each infestation, eggs were collected over a 3-h period, counted and viability determined. Dogs were combed to remove any remaining fleas. Results Treatment of dogs with oral fluralaner provided a 100 % reduction in flea counts 48 h after treatment and within 48 h of every post-treatment infestation through Day122. Egg production from fluralaner treated dogs was reduced by 99.9 % (two eggs from one dog) within 48 h after treatment and not a single egg (100 % efficacy) was thereafter collected from treated dogs. Adult flea counts and egg production from the fluralaner-treated dogs were significantly lower than for non-treated controls at all post-treatment evaluations (P < 0.001). The two eggs collected from the single treated dog 48 h after treatment did not produce any adult fleas. As no additional eggs were collected from treated dogs, no viability assessment was performed. Conclusions A single oral dose of fluralaner flavored chews provided 100 % efficacy against repeated flea infestations on dogs for 4 months. Fluralaner reduced egg production of activity reproducing female fleas by 99.9 % and then killed every single female flea before any eggs could be produced following each subsequent re-infestation for the entire 122-day evaluation period.https://doi.org/10.1186/s13071-015-0965-4FleaCtenocephalides felis felisCat fleaDogsFluralanerEgg production |
| spellingShingle | Michael W Dryden Vicki Smith Tashina Bennett Lisa Math James Kallman Kathleen Heaney Fangshi Sun Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production Parasites & Vectors Flea Ctenocephalides felis felis Cat flea Dogs Fluralaner Egg production |
| title | Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production |
| title_full | Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production |
| title_fullStr | Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production |
| title_full_unstemmed | Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production |
| title_short | Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production |
| title_sort | efficacy of fluralaner flavored chews bravecto r administered to dogs against the adult cat flea ctenocephalides felis felis and egg production |
| topic | Flea Ctenocephalides felis felis Cat flea Dogs Fluralaner Egg production |
| url | https://doi.org/10.1186/s13071-015-0965-4 |
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