The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host
Abnormal metabolic alterations of cancer cells and the host play critical roles in the occurrence and development of tumors. Targeting cancer cells and host metabolism can provide novel diagnosis indicators and intervention targets for tumors. In recent years, it has been found that gut microbiota i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1029033/full |
| _version_ | 1797988531722780672 |
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| author | Jia-Ting Huang Jia-Ting Huang Yu-Qin Mao Yu-Qin Mao |
| author_facet | Jia-Ting Huang Jia-Ting Huang Yu-Qin Mao Yu-Qin Mao |
| author_sort | Jia-Ting Huang |
| collection | DOAJ |
| description | Abnormal metabolic alterations of cancer cells and the host play critical roles in the occurrence and development of tumors. Targeting cancer cells and host metabolism can provide novel diagnosis indicators and intervention targets for tumors. In recent years, it has been found that gut microbiota is involved in the metabolism of the host and cancer cells. Increasingly, gut microbiome and their metabolites have been demonstrated great influence on the tumor formation, prognosis and treatment. Specific gut microbial composition and metabolites are associated with the status of tumor in the host. Interventions on the gut microbiota can exert the protective effects on the tumor, through the manipulation of structure and its related metabolites. This may be the new approach to improve the efficacy of tumor prevention and treatment. Here, we discuss the effects and the underlying mechanisms of gut microbiota and microbial-derived metabolites in tumor progression and treatment. |
| first_indexed | 2024-04-11T08:05:32Z |
| format | Article |
| id | doaj.art-18cbd63862b5460db5c1d9108df72d68 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T08:05:32Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-18cbd63862b5460db5c1d9108df72d682022-12-22T04:35:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10290331029033The impact of the microbiome in cancer: Targeting metabolism of cancer cells and hostJia-Ting Huang0Jia-Ting Huang1Yu-Qin Mao2Yu-Qin Mao3Center for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, ChinaInstitute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, ChinaCenter for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, ChinaInstitute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, ChinaAbnormal metabolic alterations of cancer cells and the host play critical roles in the occurrence and development of tumors. Targeting cancer cells and host metabolism can provide novel diagnosis indicators and intervention targets for tumors. In recent years, it has been found that gut microbiota is involved in the metabolism of the host and cancer cells. Increasingly, gut microbiome and their metabolites have been demonstrated great influence on the tumor formation, prognosis and treatment. Specific gut microbial composition and metabolites are associated with the status of tumor in the host. Interventions on the gut microbiota can exert the protective effects on the tumor, through the manipulation of structure and its related metabolites. This may be the new approach to improve the efficacy of tumor prevention and treatment. Here, we discuss the effects and the underlying mechanisms of gut microbiota and microbial-derived metabolites in tumor progression and treatment.https://www.frontiersin.org/articles/10.3389/fonc.2022.1029033/fulltumormicrobiomemetabolismhosttherapy |
| spellingShingle | Jia-Ting Huang Jia-Ting Huang Yu-Qin Mao Yu-Qin Mao The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host Frontiers in Oncology tumor microbiome metabolism host therapy |
| title | The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host |
| title_full | The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host |
| title_fullStr | The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host |
| title_full_unstemmed | The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host |
| title_short | The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host |
| title_sort | impact of the microbiome in cancer targeting metabolism of cancer cells and host |
| topic | tumor microbiome metabolism host therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1029033/full |
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