Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital
This study aimed to evaluate the type and severity of neurological involvement in children with SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) and compare these findings between the two groups. Children hospitalized with the diagnosis of COVID-19 or MIS-C at Meyer Chil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/12/1809 |
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| author | Giulia Abbati Federica Attaianese Anna Rosati Giuseppe Indolfi Sandra Trapani |
| author_facet | Giulia Abbati Federica Attaianese Anna Rosati Giuseppe Indolfi Sandra Trapani |
| author_sort | Giulia Abbati |
| collection | DOAJ |
| description | This study aimed to evaluate the type and severity of neurological involvement in children with SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) and compare these findings between the two groups. Children hospitalized with the diagnosis of COVID-19 or MIS-C at Meyer Children’s Hospital between February 2020 and June 2022 were retrospectively studied. One hundred twenty-two patients were enrolled, 95 in the COVID-19 group and 27 in the MIS-C group. In the COVID-19 group, impairment of consciousness was found in 67.4% of patients, headache in 18.9% and about 16.8% of patients experienced seizures. In this group, three patients were diagnosed with arterial ischemic stroke and one patient was diagnosed with Guillain-Barré syndrome (GBS). In the MIS-C group, about 70% of patients experienced consciousness impairment, about 20% behavioral changes, and another 20% mood deflection. Neurological symptoms and signs were highly heterogeneous and could be differentiated in COVID-19 and MIS-C. Consciousness impairment remained the most frequent manifestation in both groups, potentially underlying an encephalopathy. We also highlight the importance of considering psychiatric symptoms in children with COVID-19 and/or MIS-C. Most neurological manifestations were mild in our series; however, severe complications such as ischemic stroke and GBS are worthy of note. |
| first_indexed | 2024-03-09T17:11:06Z |
| format | Article |
| id | doaj.art-18cd8075964244c7919212bd155c4573 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T17:11:06Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-18cd8075964244c7919212bd155c45732023-11-24T14:00:08ZengMDPI AGChildren2227-90672022-11-01912180910.3390/children9121809Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric HospitalGiulia Abbati0Federica Attaianese1Anna Rosati2Giuseppe Indolfi3Sandra Trapani4Paediatric Residency, Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyPaediatric Residency, Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyNeurology Unit, Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyNEUROFARBA Department, University of Florence, Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyThis study aimed to evaluate the type and severity of neurological involvement in children with SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) and compare these findings between the two groups. Children hospitalized with the diagnosis of COVID-19 or MIS-C at Meyer Children’s Hospital between February 2020 and June 2022 were retrospectively studied. One hundred twenty-two patients were enrolled, 95 in the COVID-19 group and 27 in the MIS-C group. In the COVID-19 group, impairment of consciousness was found in 67.4% of patients, headache in 18.9% and about 16.8% of patients experienced seizures. In this group, three patients were diagnosed with arterial ischemic stroke and one patient was diagnosed with Guillain-Barré syndrome (GBS). In the MIS-C group, about 70% of patients experienced consciousness impairment, about 20% behavioral changes, and another 20% mood deflection. Neurological symptoms and signs were highly heterogeneous and could be differentiated in COVID-19 and MIS-C. Consciousness impairment remained the most frequent manifestation in both groups, potentially underlying an encephalopathy. We also highlight the importance of considering psychiatric symptoms in children with COVID-19 and/or MIS-C. Most neurological manifestations were mild in our series; however, severe complications such as ischemic stroke and GBS are worthy of note.https://www.mdpi.com/2227-9067/9/12/1809neurological involvementchildrenpediatricSARS-CoV-2COVID-19MIS-C |
| spellingShingle | Giulia Abbati Federica Attaianese Anna Rosati Giuseppe Indolfi Sandra Trapani Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital Children neurological involvement children pediatric SARS-CoV-2 COVID-19 MIS-C |
| title | Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital |
| title_full | Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital |
| title_fullStr | Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital |
| title_full_unstemmed | Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital |
| title_short | Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital |
| title_sort | neurological involvement in children with covid 19 and mis c a retrospective study conducted for more than two years in a pediatric hospital |
| topic | neurological involvement children pediatric SARS-CoV-2 COVID-19 MIS-C |
| url | https://www.mdpi.com/2227-9067/9/12/1809 |
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