Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study
It is well established that certain alteration of sleep disorders occur in patients with wake-up stroke (WUS) such as sleep disordered breathing, periodic limb movements and sleep duration. However, the data are lacking about the microarchitecture of different sleep stages among those patients. Aim...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Neurobiology of Sleep and Circadian Rhythms |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451994421000109 |
| _version_ | 1819009076597620736 |
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| author | Jaidaa Mekky Osama El-Kholy Eman Hamdy Akram Fawzy |
| author_facet | Jaidaa Mekky Osama El-Kholy Eman Hamdy Akram Fawzy |
| author_sort | Jaidaa Mekky |
| collection | DOAJ |
| description | It is well established that certain alteration of sleep disorders occur in patients with wake-up stroke (WUS) such as sleep disordered breathing, periodic limb movements and sleep duration. However, the data are lacking about the microarchitecture of different sleep stages among those patients. Aim of work: To compare the polysomnographic microarchitecture of rapid eye movement (REM) sleep between WUS and daytime stroke (DTS). Methods: A cross-sectional polysomnographic study was conducted on 20 patients with WUS and 20 patients with DTS, with analysis of REM sleep microarchitecture in specific. Results: Patients with WUS had significantly shorter REM stage (11.76 ± 5.48% in WUS versus 16.59 ± 5.33% in DTS, P = 0.008), longer early morning REM was (25.70 ± 13.13 min in WUS versus 4.15 ± 4.69 min in DTS, P=<0.001), higher apnea-hypopnea index (AHI) during REM (6.29 ± 10.18 in WUS versus 1.10 ± 4.57 in DTS, P = 0.009), and lower mean Oxygen saturation during REM (92.70 ± 3.63 WUS versus 95.45 ± 1.35 DTS, P = 0.012). The OR of early morning REM duration was 1.8 (CI 1.099–3.130, p = 0.021) for WUS. Conclusion: The microarchitecture of REM sleep is disrupted in patients with wake-up stroke. |
| first_indexed | 2024-12-21T00:50:37Z |
| format | Article |
| id | doaj.art-18ce99689e0b4575943905b7898d6135 |
| institution | Directory Open Access Journal |
| issn | 2451-9944 |
| language | English |
| last_indexed | 2024-12-21T00:50:37Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Sleep and Circadian Rhythms |
| spelling | doaj.art-18ce99689e0b4575943905b7898d61352022-12-21T19:21:24ZengElsevierNeurobiology of Sleep and Circadian Rhythms2451-99442021-11-0111100069Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic studyJaidaa Mekky0Osama El-Kholy1Eman Hamdy2Akram Fawzy3Corresponding author. 18, Mina Street, Kafr Abdou.21311, Department of Neuropsychiatry, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Department of Neuropsychiatry, Faculty of Medicine, Alexandria University, Alexandria, EgyptDepartment of Neuropsychiatry, Faculty of Medicine, Alexandria University, Alexandria, EgyptDepartment of Neuropsychiatry, Faculty of Medicine, Alexandria University, Alexandria, EgyptDepartment of Neuropsychiatry, Faculty of Medicine, Alexandria University, Alexandria, EgyptIt is well established that certain alteration of sleep disorders occur in patients with wake-up stroke (WUS) such as sleep disordered breathing, periodic limb movements and sleep duration. However, the data are lacking about the microarchitecture of different sleep stages among those patients. Aim of work: To compare the polysomnographic microarchitecture of rapid eye movement (REM) sleep between WUS and daytime stroke (DTS). Methods: A cross-sectional polysomnographic study was conducted on 20 patients with WUS and 20 patients with DTS, with analysis of REM sleep microarchitecture in specific. Results: Patients with WUS had significantly shorter REM stage (11.76 ± 5.48% in WUS versus 16.59 ± 5.33% in DTS, P = 0.008), longer early morning REM was (25.70 ± 13.13 min in WUS versus 4.15 ± 4.69 min in DTS, P=<0.001), higher apnea-hypopnea index (AHI) during REM (6.29 ± 10.18 in WUS versus 1.10 ± 4.57 in DTS, P = 0.009), and lower mean Oxygen saturation during REM (92.70 ± 3.63 WUS versus 95.45 ± 1.35 DTS, P = 0.012). The OR of early morning REM duration was 1.8 (CI 1.099–3.130, p = 0.021) for WUS. Conclusion: The microarchitecture of REM sleep is disrupted in patients with wake-up stroke.http://www.sciencedirect.com/science/article/pii/S2451994421000109SleepCerebrovascular strokePolysomnographyDaytime strokeWakeup stroke |
| spellingShingle | Jaidaa Mekky Osama El-Kholy Eman Hamdy Akram Fawzy Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study Neurobiology of Sleep and Circadian Rhythms Sleep Cerebrovascular stroke Polysomnography Daytime stroke Wakeup stroke |
| title | Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study |
| title_full | Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study |
| title_fullStr | Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study |
| title_full_unstemmed | Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study |
| title_short | Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study |
| title_sort | rapid eye movement rem sleep microarchitecture is altered in patients with wake up ischemic stroke a polysomnographic study |
| topic | Sleep Cerebrovascular stroke Polysomnography Daytime stroke Wakeup stroke |
| url | http://www.sciencedirect.com/science/article/pii/S2451994421000109 |
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