Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer Subtypes
Adenoid cystic carcinoma/basaloid cell carcinoma of the prostate (ACC/BCC) is a very rare variant of prostate cancer with uncertain behavior. Few cases are reported in the literature. Data on treatment options are scarce. The aim of our work was to retrospectively review the published reports. Thirt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/3/152 |
| _version_ | 1827649435137474560 |
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| author | Salvatore Cozzi Lilia Bardoscia Masoumeh Najafi Andrea Botti Gladys Blandino Matteo Augugliaro Moana Manicone Federico Iori Lucia Giaccherini Angela Sardaro Cinzia Iotti Patrizia Ciammella |
| author_facet | Salvatore Cozzi Lilia Bardoscia Masoumeh Najafi Andrea Botti Gladys Blandino Matteo Augugliaro Moana Manicone Federico Iori Lucia Giaccherini Angela Sardaro Cinzia Iotti Patrizia Ciammella |
| author_sort | Salvatore Cozzi |
| collection | DOAJ |
| description | Adenoid cystic carcinoma/basaloid cell carcinoma of the prostate (ACC/BCC) is a very rare variant of prostate cancer with uncertain behavior. Few cases are reported in the literature. Data on treatment options are scarce. The aim of our work was to retrospectively review the published reports. Thirty-three case reports or case series were analyzed (106 patients in total). Pathological features, management, and follow-up information were evaluated. Despite the relatively low level of evidence given the unavoidable lack of prospective trials for such a rare prostate tumor, the following considerations were made: prostate ACC/BCC is an aggressive tumor often presenting with locally advanced disease and incidental diagnosis occurs during transurethral resection of the prostate for urinary obstructive symptoms. Prostate-specific antigen was not a reliable marker for diagnosis nor follow-up. Adequate staging with Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI) should be performed before treatment and during follow-up, while there is no evidence for the use of Positron Emission Tomography (PET). Radical surgery with negative margins and possibly adjuvant radiotherapy appear to be the treatments of choice. The response to androgen deprivation therapy was poor. Currently, there is no evidence of the use of truly effective systemic therapies. |
| first_indexed | 2024-03-09T19:56:42Z |
| format | Article |
| id | doaj.art-18cfe57fed6f45b792260bc6fe99f580 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T19:56:42Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-18cfe57fed6f45b792260bc6fe99f5802023-11-24T00:53:15ZengMDPI AGCurrent Oncology1198-00521718-77292022-03-012931866187610.3390/curroncol29030152Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer SubtypesSalvatore Cozzi0Lilia Bardoscia1Masoumeh Najafi2Andrea Botti3Gladys Blandino4Matteo Augugliaro5Moana Manicone6Federico Iori7Lucia Giaccherini8Angela Sardaro9Cinzia Iotti10Patrizia Ciammella11Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyRadiation Oncology Unit, S. Luca Hospital, Healthcare Company Tuscany Nord Ovest, 55100 Lucca, ItalyDepartment of Radiation Oncology Shohadaye Haft-e-Tir Hospital, Iran University of Medical Science, Teheran 1449614535, IranMedical Physics Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyInterdisciplinary Department of Medicine, Section of Radiology and Radiation Oncology, University of Bari Aldo Moro, 70124 Bari, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyAdenoid cystic carcinoma/basaloid cell carcinoma of the prostate (ACC/BCC) is a very rare variant of prostate cancer with uncertain behavior. Few cases are reported in the literature. Data on treatment options are scarce. The aim of our work was to retrospectively review the published reports. Thirty-three case reports or case series were analyzed (106 patients in total). Pathological features, management, and follow-up information were evaluated. Despite the relatively low level of evidence given the unavoidable lack of prospective trials for such a rare prostate tumor, the following considerations were made: prostate ACC/BCC is an aggressive tumor often presenting with locally advanced disease and incidental diagnosis occurs during transurethral resection of the prostate for urinary obstructive symptoms. Prostate-specific antigen was not a reliable marker for diagnosis nor follow-up. Adequate staging with Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI) should be performed before treatment and during follow-up, while there is no evidence for the use of Positron Emission Tomography (PET). Radical surgery with negative margins and possibly adjuvant radiotherapy appear to be the treatments of choice. The response to androgen deprivation therapy was poor. Currently, there is no evidence of the use of truly effective systemic therapies.https://www.mdpi.com/1718-7729/29/3/152adenoid cystic carcinomabasaloid cell carcinomaprostate cancersurgeryradiotherapyrare tumor variants |
| spellingShingle | Salvatore Cozzi Lilia Bardoscia Masoumeh Najafi Andrea Botti Gladys Blandino Matteo Augugliaro Moana Manicone Federico Iori Lucia Giaccherini Angela Sardaro Cinzia Iotti Patrizia Ciammella Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer Subtypes Current Oncology adenoid cystic carcinoma basaloid cell carcinoma prostate cancer surgery radiotherapy rare tumor variants |
| title | Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer Subtypes |
| title_full | Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer Subtypes |
| title_fullStr | Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer Subtypes |
| title_full_unstemmed | Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer Subtypes |
| title_short | Adenoid Cystic Carcinoma/Basal Cell Carcinoma of the Prostate: Overview and Update on Rare Prostate Cancer Subtypes |
| title_sort | adenoid cystic carcinoma basal cell carcinoma of the prostate overview and update on rare prostate cancer subtypes |
| topic | adenoid cystic carcinoma basaloid cell carcinoma prostate cancer surgery radiotherapy rare tumor variants |
| url | https://www.mdpi.com/1718-7729/29/3/152 |
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