The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis. Materials and Methods: One hundred patients with rheumatoid arthritis involved in this study, consi...
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Format: | Article |
Language: | English |
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Cukurova University
2014-08-01
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Series: | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
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Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=156779 |
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author | Raouf Rahim Merza Dana Mohammed Tofiq Najlaa Naser Radhi Hawar Ali Ehsan Kaka Khan |
author_facet | Raouf Rahim Merza Dana Mohammed Tofiq Najlaa Naser Radhi Hawar Ali Ehsan Kaka Khan |
author_sort | Raouf Rahim Merza |
collection | DOAJ |
description | Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis.
Materials and Methods: One hundred patients with rheumatoid arthritis involved in this study, consisted of 88 female and 12 male who fulfilled the 2010 ACR-EULAR classification criteria for rheumatoid arthritis attending the rheumatology department in general hospital, or attended the center of rheumatology and rehabilitation in sulaimani city, for 6 months ( from October, 2012 to March, 2013).
Thorough Demographic information of patients was recorded through history of age, sex, and history of smoking, disease duration, physical evaluation according to DAS-28. and serological test for RF and Anti-CCP.
Results: There was highly significant association between DAS-28 and Anti-CCP value (p =0.0001). there was no significant correlation between DAS-28 and RF (p= 0.252),According to smoking there was highly significant association between smoking with Anti-CCP value and DAS-28 (p=0.003- 0.0001) respectively while there was no significant association between smoking and RF(p=0.15).
Conclusion: A highly significant correlation was found between Anti-CCP value and disease activity in rheumatoid arthritis, smoker patients had higher value of Anti-CCP compared to non-smoker patients. Smokers demonstrated a more active and severe disease activity compared to non-smokers. [Cukurova Med J 2014; 39(4.000): 743-751] |
first_indexed | 2024-04-10T13:33:07Z |
format | Article |
id | doaj.art-18d090a693c74ecabbbb2bebaedbb850 |
institution | Directory Open Access Journal |
issn | 0250-5150 |
language | English |
last_indexed | 2024-04-10T13:33:07Z |
publishDate | 2014-08-01 |
publisher | Cukurova University |
record_format | Article |
series | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
spelling | doaj.art-18d090a693c74ecabbbb2bebaedbb8502023-02-15T16:11:30ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502014-08-01394743751156779The Association of Anti-CCP and Disease Activity in Rheumatoid ArthritisRaouf Rahim Merza0Dana Mohammed Tofiq1Najlaa Naser Radhi2Hawar Ali Ehsan Kaka Khan3Sulaimaniya Medical School _ Iraq Sulaimaniya Medical School _ Iraq. Kirkuk General Hospital. Sulaimaniya General Hospital.Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis. Materials and Methods: One hundred patients with rheumatoid arthritis involved in this study, consisted of 88 female and 12 male who fulfilled the 2010 ACR-EULAR classification criteria for rheumatoid arthritis attending the rheumatology department in general hospital, or attended the center of rheumatology and rehabilitation in sulaimani city, for 6 months ( from October, 2012 to March, 2013). Thorough Demographic information of patients was recorded through history of age, sex, and history of smoking, disease duration, physical evaluation according to DAS-28. and serological test for RF and Anti-CCP. Results: There was highly significant association between DAS-28 and Anti-CCP value (p =0.0001). there was no significant correlation between DAS-28 and RF (p= 0.252),According to smoking there was highly significant association between smoking with Anti-CCP value and DAS-28 (p=0.003- 0.0001) respectively while there was no significant association between smoking and RF(p=0.15). Conclusion: A highly significant correlation was found between Anti-CCP value and disease activity in rheumatoid arthritis, smoker patients had higher value of Anti-CCP compared to non-smoker patients. Smokers demonstrated a more active and severe disease activity compared to non-smokers. [Cukurova Med J 2014; 39(4.000): 743-751]http://www.scopemed.org/fulltextpdf.php?mno=156779Rheumatoid arthritisDAS-28Anti-CCP,RF |
spellingShingle | Raouf Rahim Merza Dana Mohammed Tofiq Najlaa Naser Radhi Hawar Ali Ehsan Kaka Khan The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis Çukurova Üniversitesi Tıp Fakültesi Dergisi Rheumatoid arthritis DAS-28 Anti-CCP,RF |
title | The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis |
title_full | The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis |
title_fullStr | The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis |
title_full_unstemmed | The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis |
title_short | The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis |
title_sort | association of anti ccp and disease activity in rheumatoid arthritis |
topic | Rheumatoid arthritis DAS-28 Anti-CCP,RF |
url | http://www.scopemed.org/fulltextpdf.php?mno=156779 |
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