The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis

Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis. Materials and Methods: One hundred patients with rheumatoid arthritis involved in this study, consi...

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Main Authors: Raouf Rahim Merza, Dana Mohammed Tofiq, Najlaa Naser Radhi, Hawar Ali Ehsan Kaka Khan
Format: Article
Language:English
Published: Cukurova University 2014-08-01
Series:Çukurova Üniversitesi Tıp Fakültesi Dergisi
Subjects:
Online Access:http://www.scopemed.org/fulltextpdf.php?mno=156779
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author Raouf Rahim Merza
Dana Mohammed Tofiq
Najlaa Naser Radhi
Hawar Ali Ehsan Kaka Khan
author_facet Raouf Rahim Merza
Dana Mohammed Tofiq
Najlaa Naser Radhi
Hawar Ali Ehsan Kaka Khan
author_sort Raouf Rahim Merza
collection DOAJ
description Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis. Materials and Methods: One hundred patients with rheumatoid arthritis involved in this study, consisted of 88 female and 12 male who fulfilled the 2010 ACR-EULAR classification criteria for rheumatoid arthritis attending the rheumatology department in general hospital, or attended the center of rheumatology and rehabilitation in sulaimani city, for 6 months ( from October, 2012 to March, 2013). Thorough Demographic information of patients was recorded through history of age, sex, and history of smoking, disease duration, physical evaluation according to DAS-28. and serological test for RF and Anti-CCP. Results: There was highly significant association between DAS-28 and Anti-CCP value (p =0.0001). there was no significant correlation between DAS-28 and RF (p= 0.252),According to smoking there was highly significant association between smoking with Anti-CCP value and DAS-28 (p=0.003- 0.0001) respectively while there was no significant association between smoking and RF(p=0.15). Conclusion: A highly significant correlation was found between Anti-CCP value and disease activity in rheumatoid arthritis, smoker patients had higher value of Anti-CCP compared to non-smoker patients. Smokers demonstrated a more active and severe disease activity compared to non-smokers. [Cukurova Med J 2014; 39(4.000): 743-751]
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spelling doaj.art-18d090a693c74ecabbbb2bebaedbb8502023-02-15T16:11:30ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502014-08-01394743751156779The Association of Anti-CCP and Disease Activity in Rheumatoid ArthritisRaouf Rahim Merza0Dana Mohammed Tofiq1Najlaa Naser Radhi2Hawar Ali Ehsan Kaka Khan3Sulaimaniya Medical School _ Iraq Sulaimaniya Medical School _ Iraq. Kirkuk General Hospital. Sulaimaniya General Hospital.Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis. Materials and Methods: One hundred patients with rheumatoid arthritis involved in this study, consisted of 88 female and 12 male who fulfilled the 2010 ACR-EULAR classification criteria for rheumatoid arthritis attending the rheumatology department in general hospital, or attended the center of rheumatology and rehabilitation in sulaimani city, for 6 months ( from October, 2012 to March, 2013). Thorough Demographic information of patients was recorded through history of age, sex, and history of smoking, disease duration, physical evaluation according to DAS-28. and serological test for RF and Anti-CCP. Results: There was highly significant association between DAS-28 and Anti-CCP value (p =0.0001). there was no significant correlation between DAS-28 and RF (p= 0.252),According to smoking there was highly significant association between smoking with Anti-CCP value and DAS-28 (p=0.003- 0.0001) respectively while there was no significant association between smoking and RF(p=0.15). Conclusion: A highly significant correlation was found between Anti-CCP value and disease activity in rheumatoid arthritis, smoker patients had higher value of Anti-CCP compared to non-smoker patients. Smokers demonstrated a more active and severe disease activity compared to non-smokers. [Cukurova Med J 2014; 39(4.000): 743-751]http://www.scopemed.org/fulltextpdf.php?mno=156779Rheumatoid arthritisDAS-28Anti-CCP,RF
spellingShingle Raouf Rahim Merza
Dana Mohammed Tofiq
Najlaa Naser Radhi
Hawar Ali Ehsan Kaka Khan
The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
Çukurova Üniversitesi Tıp Fakültesi Dergisi
Rheumatoid arthritis
DAS-28
Anti-CCP,RF
title The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
title_full The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
title_fullStr The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
title_full_unstemmed The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
title_short The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
title_sort association of anti ccp and disease activity in rheumatoid arthritis
topic Rheumatoid arthritis
DAS-28
Anti-CCP,RF
url http://www.scopemed.org/fulltextpdf.php?mno=156779
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