LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels
Abstract Background Visceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabolic syndrome and diabetes mellitus. However, their genetic determinants...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-018-0383-9 |
| _version_ | 1818021099201363968 |
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| author | Ming-Sheng Teng Semon Wu Leay-Kiaw Er Lung-An Hsu Hsin-Hua Chou Yu-Lin Ko |
| author_facet | Ming-Sheng Teng Semon Wu Leay-Kiaw Er Lung-An Hsu Hsin-Hua Chou Yu-Lin Ko |
| author_sort | Ming-Sheng Teng |
| collection | DOAJ |
| description | Abstract Background Visceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabolic syndrome and diabetes mellitus. However, their genetic determinants have not been previously reported. Pleiotropic associations of LIPC variants have been observed in lipid profiles and atherosclerotic cardiovascular diseases. We aimed to investigate LIPC polymorphisms as the genetic determinants of adiposity status, visceral adiposity indicators and TyG index-related parameters. Methods A total of 592 participants from Taiwan were genotyped for three LIPC single nucleotide polymorphisms (SNPs). Results The LIPC SNPs rs2043085 and rs1532085 were significantly associated with body mass index (BMI), waist circumference (WC), lipid accumulation product, visceral adiposity index, and TyG index-related parameters [including the TyG index, TyG with adiposity status (TyG-BMI), and TyG-WC index], whereas the rs1800588 SNP was only significantly associated with the TyG index. The associations became nonsignificant after further adjustment for serum TG levels. No significant association was observed between any the studied LIPC SNPs and IR status. Conclusion Our data revealed a pleiotropic association between the LIPC variants and visceral adiposity indicators and TyG index-related parameters, which are mediated by serum TG levels. |
| first_indexed | 2024-04-14T08:13:27Z |
| format | Article |
| id | doaj.art-18d0a3076d494827ac9038bb89afe4c6 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-14T08:13:27Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-18d0a3076d494827ac9038bb89afe4c62022-12-22T02:04:28ZengBMCDiabetology & Metabolic Syndrome1758-59962018-11-0110111010.1186/s13098-018-0383-9LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levelsMing-Sheng Teng0Semon Wu1Leay-Kiaw Er2Lung-An Hsu3Hsin-Hua Chou4Yu-Lin Ko5Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationThe Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationFirst Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of MedicineCardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationAbstract Background Visceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabolic syndrome and diabetes mellitus. However, their genetic determinants have not been previously reported. Pleiotropic associations of LIPC variants have been observed in lipid profiles and atherosclerotic cardiovascular diseases. We aimed to investigate LIPC polymorphisms as the genetic determinants of adiposity status, visceral adiposity indicators and TyG index-related parameters. Methods A total of 592 participants from Taiwan were genotyped for three LIPC single nucleotide polymorphisms (SNPs). Results The LIPC SNPs rs2043085 and rs1532085 were significantly associated with body mass index (BMI), waist circumference (WC), lipid accumulation product, visceral adiposity index, and TyG index-related parameters [including the TyG index, TyG with adiposity status (TyG-BMI), and TyG-WC index], whereas the rs1800588 SNP was only significantly associated with the TyG index. The associations became nonsignificant after further adjustment for serum TG levels. No significant association was observed between any the studied LIPC SNPs and IR status. Conclusion Our data revealed a pleiotropic association between the LIPC variants and visceral adiposity indicators and TyG index-related parameters, which are mediated by serum TG levels.http://link.springer.com/article/10.1186/s13098-018-0383-9Hepatic lipaseSingle-nucleotide polymorphismTriglyceride levelHigh-density lipoprotein cholesterol levelAdiposity statusVisceral adiposity indicators |
| spellingShingle | Ming-Sheng Teng Semon Wu Leay-Kiaw Er Lung-An Hsu Hsin-Hua Chou Yu-Lin Ko LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels Diabetology & Metabolic Syndrome Hepatic lipase Single-nucleotide polymorphism Triglyceride level High-density lipoprotein cholesterol level Adiposity status Visceral adiposity indicators |
| title | LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels |
| title_full | LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels |
| title_fullStr | LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels |
| title_full_unstemmed | LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels |
| title_short | LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels |
| title_sort | lipc variants as genetic determinants of adiposity status visceral adiposity indicators and triglyceride glucose tyg index related parameters mediated by serum triglyceride levels |
| topic | Hepatic lipase Single-nucleotide polymorphism Triglyceride level High-density lipoprotein cholesterol level Adiposity status Visceral adiposity indicators |
| url | http://link.springer.com/article/10.1186/s13098-018-0383-9 |
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