Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders
Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications t...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4691 |
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| author | Tomás Cerdó José Antonio García-Santos Anna Rodríguez-Pöhnlein María García-Ricobaraza Ana Nieto-Ruíz Mercedes G. Bermúdez Cristina Campoy |
| author_facet | Tomás Cerdó José Antonio García-Santos Anna Rodríguez-Pöhnlein María García-Ricobaraza Ana Nieto-Ruíz Mercedes G. Bermúdez Cristina Campoy |
| author_sort | Tomás Cerdó |
| collection | DOAJ |
| description | Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potential use of pre-, pro- and/or synbiotics as promising therapeutic strategies to reduce the risk of severe gastrointestinal disorders and mortality. The findings discussed here highlight the need for more well-designed studies, and harmonize the methods and its interpretation, which are critical to better understand the role of the gut microbiota in PN-related diseases and the development of efficient and personalized approaches based on pro- and/or prebiotics. |
| first_indexed | 2024-03-09T18:45:44Z |
| format | Article |
| id | doaj.art-18d193d639b64f088ae9cd9d9f7eb718 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:45:44Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-18d193d639b64f088ae9cd9d9f7eb7182023-11-24T06:15:43ZengMDPI AGNutrients2072-66432022-11-011421469110.3390/nu14214691Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal DisordersTomás Cerdó0José Antonio García-Santos1Anna Rodríguez-Pöhnlein2María García-Ricobaraza3Ana Nieto-Ruíz4Mercedes G. Bermúdez5Cristina Campoy6Maimonides Institute for Research in Biomedicine of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, 14004 Córdoba, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, SpainParenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potential use of pre-, pro- and/or synbiotics as promising therapeutic strategies to reduce the risk of severe gastrointestinal disorders and mortality. The findings discussed here highlight the need for more well-designed studies, and harmonize the methods and its interpretation, which are critical to better understand the role of the gut microbiota in PN-related diseases and the development of efficient and personalized approaches based on pro- and/or prebiotics.https://www.mdpi.com/2072-6643/14/21/4691total parenteral nutrition (TPN)gut microbiota dysbiosispediatric populationinflammatory bowel disease (IBD)necrotizing enterocolitis (NEC)parenteral nutrition-associated liver disease (PNAD) |
| spellingShingle | Tomás Cerdó José Antonio García-Santos Anna Rodríguez-Pöhnlein María García-Ricobaraza Ana Nieto-Ruíz Mercedes G. Bermúdez Cristina Campoy Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders Nutrients total parenteral nutrition (TPN) gut microbiota dysbiosis pediatric population inflammatory bowel disease (IBD) necrotizing enterocolitis (NEC) parenteral nutrition-associated liver disease (PNAD) |
| title | Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders |
| title_full | Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders |
| title_fullStr | Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders |
| title_full_unstemmed | Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders |
| title_short | Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders |
| title_sort | impact of total parenteral nutrition on gut microbiota in pediatric population suffering intestinal disorders |
| topic | total parenteral nutrition (TPN) gut microbiota dysbiosis pediatric population inflammatory bowel disease (IBD) necrotizing enterocolitis (NEC) parenteral nutrition-associated liver disease (PNAD) |
| url | https://www.mdpi.com/2072-6643/14/21/4691 |
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