Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and tra...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2019.00272/full |
| _version_ | 1818200910308835328 |
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| author | Haopeng Yang Michael R. Green Michael R. Green |
| author_facet | Haopeng Yang Michael R. Green Michael R. Green |
| author_sort | Haopeng Yang |
| collection | DOAJ |
| description | B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage. The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma. Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations. We underscore the critical importance of BCL6 and its associated epigenetic programs in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context. |
| first_indexed | 2024-12-12T02:45:10Z |
| format | Article |
| id | doaj.art-18d240addcc646bea3fec1c867bf5716 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T02:45:10Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-18d240addcc646bea3fec1c867bf57162022-12-22T00:41:03ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2019-11-01710.3389/fcell.2019.00272483218Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic DeregulationHaopeng Yang0Michael R. Green1Michael R. Green2Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesB cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage. The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma. Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations. We underscore the critical importance of BCL6 and its associated epigenetic programs in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context.https://www.frontiersin.org/article/10.3389/fcell.2019.00272/fullBCL6chromatin modifying geneshistone acetylationhistone methylationB-cell lymphomagerminal center |
| spellingShingle | Haopeng Yang Michael R. Green Michael R. Green Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation Frontiers in Cell and Developmental Biology BCL6 chromatin modifying genes histone acetylation histone methylation B-cell lymphoma germinal center |
| title | Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation |
| title_full | Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation |
| title_fullStr | Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation |
| title_full_unstemmed | Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation |
| title_short | Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation |
| title_sort | epigenetic programing of b cell lymphoma by bcl6 and its genetic deregulation |
| topic | BCL6 chromatin modifying genes histone acetylation histone methylation B-cell lymphoma germinal center |
| url | https://www.frontiersin.org/article/10.3389/fcell.2019.00272/full |
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