Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids

Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids

Summary: Disturbances in lipid metabolism in the CNS contribute to neurodegeneration and cognitive impairments. Through tight metabolic coupling, astrocytes provide energy to neurons by delivering lactate and cholesterol and by taking up and processing neuron-derived peroxidated fatty acids (pFA). D...

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Bibliographic Details
Main Authors: Kalimuthusamy Natarajaseenivasan, Alvaro Garcia, Prema Velusamy, Santhanam Shanmughapriya, Dianne Langford
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Neuroscience
Cellular neuroscience
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222016790

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