Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysis
Background: Detection of retinal β-amyloid (Aβ) peptide accumulation is a novel diagnostic method for Alzheimer’s disease (AD), but there is, as yet, no conclusive evidence of its accuracy.Aim: To identify the diagnostic accuracy of pathological retinal Aβ detection for AD by a meta-analytic approac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00267/full |
| _version_ | 1819241932536152064 |
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| author | Jiangling Jiang Hongyan Wang Wei Li Xinyi Cao Chunbo Li Chunbo Li |
| author_facet | Jiangling Jiang Hongyan Wang Wei Li Xinyi Cao Chunbo Li Chunbo Li |
| author_sort | Jiangling Jiang |
| collection | DOAJ |
| description | Background: Detection of retinal β-amyloid (Aβ) peptide accumulation is a novel diagnostic method for Alzheimer’s disease (AD), but there is, as yet, no conclusive evidence of its accuracy.Aim: To identify the diagnostic accuracy of pathological retinal Aβ detection for AD by a meta-analytic approach.Methods: Electronic and reference searches were conducted to identify studies related to the diagnostic effects of retinal Aβ detection in AD that met pre-defined inclusion criteria. The QUADAS-2 tool was employed to assess the risk of bias, and Review Manager plus the Open Meta-Analyst were used to perform the data analysis.Results: From 493 unduplicated reports, five studies with small sample sizes were included in this review. Six staining methods were employed. The eligible studies showed extremely broad ranges of sensitivity (0 to 1.00) and specificity (0.50 to 1.00) with substantial heterogeneity. The estimates of positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) were also extremely varied (from 0.71 to 11.57 for PLR, from 0.04 to 1.11 for NLR, and from 0.69 to 297.00 for DOR).Conclusions: The limited number of eligible studies and their methodological heterogeneity make it impossible to come to a conclusion whether pathological retinal Aβ detection is an effective diagnostic tool for AD. More studies, especially large surveys investigating retina Aβ load with quantitative methods among consecutive or random samples, are needed to determine the accuracy of Aβ detection for diagnosing AD. |
| first_indexed | 2024-12-23T14:31:46Z |
| format | Article |
| id | doaj.art-18d4de13c9944a0397a02b83d8139639 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-23T14:31:46Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-18d4de13c9944a0397a02b83d81396392022-12-21T17:43:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-11-01810.3389/fnagi.2016.00267219434Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysisJiangling Jiang0Hongyan Wang1Wei Li2Xinyi Cao3Chunbo Li4Chunbo Li5Shanghai Mental Health Center,Shanghai Jiao Tong University School of MedicineShanghai Mental Health Center,Shanghai Jiao Tong University School of MedicineShanghai Mental Health Center,Shanghai Jiao Tong University School of MedicineShanghai Mental Health Center,Shanghai Jiao Tong University School of MedicineShanghai Mental Health Center,Shanghai Jiao Tong University School of MedicineBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong UniversityBackground: Detection of retinal β-amyloid (Aβ) peptide accumulation is a novel diagnostic method for Alzheimer’s disease (AD), but there is, as yet, no conclusive evidence of its accuracy.Aim: To identify the diagnostic accuracy of pathological retinal Aβ detection for AD by a meta-analytic approach.Methods: Electronic and reference searches were conducted to identify studies related to the diagnostic effects of retinal Aβ detection in AD that met pre-defined inclusion criteria. The QUADAS-2 tool was employed to assess the risk of bias, and Review Manager plus the Open Meta-Analyst were used to perform the data analysis.Results: From 493 unduplicated reports, five studies with small sample sizes were included in this review. Six staining methods were employed. The eligible studies showed extremely broad ranges of sensitivity (0 to 1.00) and specificity (0.50 to 1.00) with substantial heterogeneity. The estimates of positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) were also extremely varied (from 0.71 to 11.57 for PLR, from 0.04 to 1.11 for NLR, and from 0.69 to 297.00 for DOR).Conclusions: The limited number of eligible studies and their methodological heterogeneity make it impossible to come to a conclusion whether pathological retinal Aβ detection is an effective diagnostic tool for AD. More studies, especially large surveys investigating retina Aβ load with quantitative methods among consecutive or random samples, are needed to determine the accuracy of Aβ detection for diagnosing AD.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00267/fullRetinaMeta-analysisAlzheimer’s diseasediagnosisβ-amyloid peptides |
| spellingShingle | Jiangling Jiang Hongyan Wang Wei Li Xinyi Cao Chunbo Li Chunbo Li Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysis Frontiers in Aging Neuroscience Retina Meta-analysis Alzheimer’s disease diagnosis β-amyloid peptides |
| title | Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysis |
| title_full | Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysis |
| title_fullStr | Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysis |
| title_full_unstemmed | Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysis |
| title_short | Amyloid Plaques in Retina for Diagnosis in Alzheimer’s patients: unsatisfactory results from a mata-analysis |
| title_sort | amyloid plaques in retina for diagnosis in alzheimer s patients unsatisfactory results from a mata analysis |
| topic | Retina Meta-analysis Alzheimer’s disease diagnosis β-amyloid peptides |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00267/full |
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