Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline
BackgroundLow-dose computed tomography (LDCT) has been promoted as a promising screening strategy for early detection of lung cancer. China released the latest lung cancer screening guideline in 2021. The compliance of the individuals who received LDCT for lung cancer screening with the guideline is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1085434/full |
| _version_ | 1797821130273193984 |
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| author | Zixuan Zhang Yinyan Gao Shaohui Liu Binrong Ding Xuewei Zhang Xuewei Zhang Xuewei Zhang Irene X. Y. Wu Irene X. Y. Wu |
| author_facet | Zixuan Zhang Yinyan Gao Shaohui Liu Binrong Ding Xuewei Zhang Xuewei Zhang Xuewei Zhang Irene X. Y. Wu Irene X. Y. Wu |
| author_sort | Zixuan Zhang |
| collection | DOAJ |
| description | BackgroundLow-dose computed tomography (LDCT) has been promoted as a promising screening strategy for early detection of lung cancer. China released the latest lung cancer screening guideline in 2021. The compliance of the individuals who received LDCT for lung cancer screening with the guideline is unknown yet. It is necessary to summarize the distribution of guideline-defined lung cancer–related risk factors in the Chinese population so as to inform the selection of target population for the future lung cancer screening.MethodsA single-center, cross-sectional study design was adopted. All participants were individuals who underwent LDCT at a tertiary teaching hospital in Hunan, China, between 1 January and 31 December 2021. LDCT results were derived along with guideline-based characteristics for descriptive analysis.ResultsA total of 5,486 participants were included. Over one-quarter (1,426, 26.0%) of the participants who received screening did not meet the guideline-defined high-risk population, even among non-smokers (36.4%). Most of the participants (4,622, 84.3%) were found to have lung nodules, while no clinical intervention was required basically. The detection rate of positive nodules varied from 46.8% to 71.2% when using different cut-off values for positive nodules. Among non-smoking women, ground glass opacity appeared to be more significantly common compared with non-smoking men (26.7% vs. 21.8%).ConclusionOver one-quarter of individuals who received LDCT screening did not meet the guideline-defined high-risk populations. Appropriate cut-off values for positive nodules need to be continuously explored. More precise and localized criteria for high-risk individuals are needed, especially for non-smoking women. |
| first_indexed | 2024-03-13T09:48:11Z |
| format | Article |
| id | doaj.art-18d68e06f6724e018283a6b150a995b4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T09:48:11Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-18d68e06f6724e018283a6b150a995b42023-05-24T19:25:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.10854341085434Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guidelineZixuan Zhang0Yinyan Gao1Shaohui Liu2Binrong Ding3Xuewei Zhang4Xuewei Zhang5Xuewei Zhang6Irene X. Y. Wu7Irene X. Y. Wu8Xiangya School of Public Health, Central South University, Changsha, ChinaXiangya School of Public Health, Central South University, Changsha, ChinaHealth Management Center, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Geriatrics, The Third Xiangya Hospital, Central South University, Changsha, ChinaHealth Management Center, Xiangya Hospital, Central South University, Changsha, ChinaCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Public Health, Central South University, Changsha, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, ChinaBackgroundLow-dose computed tomography (LDCT) has been promoted as a promising screening strategy for early detection of lung cancer. China released the latest lung cancer screening guideline in 2021. The compliance of the individuals who received LDCT for lung cancer screening with the guideline is unknown yet. It is necessary to summarize the distribution of guideline-defined lung cancer–related risk factors in the Chinese population so as to inform the selection of target population for the future lung cancer screening.MethodsA single-center, cross-sectional study design was adopted. All participants were individuals who underwent LDCT at a tertiary teaching hospital in Hunan, China, between 1 January and 31 December 2021. LDCT results were derived along with guideline-based characteristics for descriptive analysis.ResultsA total of 5,486 participants were included. Over one-quarter (1,426, 26.0%) of the participants who received screening did not meet the guideline-defined high-risk population, even among non-smokers (36.4%). Most of the participants (4,622, 84.3%) were found to have lung nodules, while no clinical intervention was required basically. The detection rate of positive nodules varied from 46.8% to 71.2% when using different cut-off values for positive nodules. Among non-smoking women, ground glass opacity appeared to be more significantly common compared with non-smoking men (26.7% vs. 21.8%).ConclusionOver one-quarter of individuals who received LDCT screening did not meet the guideline-defined high-risk populations. Appropriate cut-off values for positive nodules need to be continuously explored. More precise and localized criteria for high-risk individuals are needed, especially for non-smoking women.https://www.frontiersin.org/articles/10.3389/fonc.2023.1085434/fulllung cancerscreeninglow-dose computed tomographynon-smokerscharacteristics |
| spellingShingle | Zixuan Zhang Yinyan Gao Shaohui Liu Binrong Ding Xuewei Zhang Xuewei Zhang Xuewei Zhang Irene X. Y. Wu Irene X. Y. Wu Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline Frontiers in Oncology lung cancer screening low-dose computed tomography non-smokers characteristics |
| title | Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline |
| title_full | Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline |
| title_fullStr | Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline |
| title_full_unstemmed | Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline |
| title_short | Initial low-dose computed tomography screening results and summary of participant characteristics: based on the latest Chinese guideline |
| title_sort | initial low dose computed tomography screening results and summary of participant characteristics based on the latest chinese guideline |
| topic | lung cancer screening low-dose computed tomography non-smokers characteristics |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1085434/full |
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