Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis
During the last phase of HIV viral production, nascent HIV virions acquire a fraction of the cellular lipid membrane to create the external lipid envelope, a process by which cellular proteins present on the surface of the infected cell can be incorporated along with Env trimers. Interestingly, seve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/14/11/2523 |
| _version_ | 1827643554102509568 |
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| author | Olivia Munoz Riddhima Banga Matthieu Perreau |
| author_facet | Olivia Munoz Riddhima Banga Matthieu Perreau |
| author_sort | Olivia Munoz |
| collection | DOAJ |
| description | During the last phase of HIV viral production, nascent HIV virions acquire a fraction of the cellular lipid membrane to create the external lipid envelope, a process by which cellular proteins present on the surface of the infected cell can be incorporated along with Env trimers. Interestingly, several studies indicated that these incorporated host molecules could conserve their biological activity and consequently contribute to HIV pathogenesis either by enhancing the infectivity of HIV virions, their tissue tropism or by affecting immune cell functions. The following review will describe the main approaches used to characterize membrane bound host molecule incorporation into HIV virions, the proposed mechanisms involved, and the role of a non-exhaustive list of incorporated molecules. |
| first_indexed | 2024-03-09T17:55:54Z |
| format | Article |
| id | doaj.art-18d72a94b0a54b6abd686c302b23d56a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T17:55:54Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-18d72a94b0a54b6abd686c302b23d56a2023-11-24T10:18:35ZengMDPI AGViruses1999-49152022-11-011411252310.3390/v14112523Host Molecule Incorporation into HIV Virions, Potential Influences in HIV PathogenesisOlivia Munoz0Riddhima Banga1Matthieu Perreau2Division of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandDivision of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandDivision of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandDuring the last phase of HIV viral production, nascent HIV virions acquire a fraction of the cellular lipid membrane to create the external lipid envelope, a process by which cellular proteins present on the surface of the infected cell can be incorporated along with Env trimers. Interestingly, several studies indicated that these incorporated host molecules could conserve their biological activity and consequently contribute to HIV pathogenesis either by enhancing the infectivity of HIV virions, their tissue tropism or by affecting immune cell functions. The following review will describe the main approaches used to characterize membrane bound host molecule incorporation into HIV virions, the proposed mechanisms involved, and the role of a non-exhaustive list of incorporated molecules.https://www.mdpi.com/1999-4915/14/11/2523HIVreplication cycleprotein incorporationpathogenesis |
| spellingShingle | Olivia Munoz Riddhima Banga Matthieu Perreau Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis Viruses HIV replication cycle protein incorporation pathogenesis |
| title | Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis |
| title_full | Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis |
| title_fullStr | Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis |
| title_full_unstemmed | Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis |
| title_short | Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis |
| title_sort | host molecule incorporation into hiv virions potential influences in hiv pathogenesis |
| topic | HIV replication cycle protein incorporation pathogenesis |
| url | https://www.mdpi.com/1999-4915/14/11/2523 |
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