Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma
MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/7/561 |
| _version_ | 1797212753567416320 |
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| author | Lia Rodrigues Arnaud Da Cruz Paula Paula Soares João Vinagre |
| author_facet | Lia Rodrigues Arnaud Da Cruz Paula Paula Soares João Vinagre |
| author_sort | Lia Rodrigues |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting <i>DGCR8</i>, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas. |
| first_indexed | 2024-04-24T10:47:24Z |
| format | Article |
| id | doaj.art-18d8a2b90b8e4fe0b12f949dce713698 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-04-24T10:47:24Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-18d8a2b90b8e4fe0b12f949dce7136982024-04-12T13:16:23ZengMDPI AGCells2073-44092024-03-0113756110.3390/cells13070561Unraveling the Significance of DGCR8 and miRNAs in Thyroid CarcinomaLia Rodrigues0Arnaud Da Cruz Paula1Paula Soares2João Vinagre3Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, PortugalInstituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Rua Alfredo Allen, 4200-135 Porto, PortugalMicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting <i>DGCR8</i>, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas.https://www.mdpi.com/2073-4409/13/7/561microRNAsthyroid cancerDGCR8E518K |
| spellingShingle | Lia Rodrigues Arnaud Da Cruz Paula Paula Soares João Vinagre Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma Cells microRNAs thyroid cancer DGCR8 E518K |
| title | Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma |
| title_full | Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma |
| title_fullStr | Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma |
| title_full_unstemmed | Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma |
| title_short | Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma |
| title_sort | unraveling the significance of dgcr8 and mirnas in thyroid carcinoma |
| topic | microRNAs thyroid cancer DGCR8 E518K |
| url | https://www.mdpi.com/2073-4409/13/7/561 |
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