Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis
Background: Orthostatic hypotension, defined as a decrease in blood pressure on standing, is associated with an increased risk of mortality and cardiovascular events in the general population. In addition, it has recently been suggested that arterial stiffness is independently associated with orthos...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1164519/full |
| _version_ | 1797829318494126080 |
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| author | Alicia Saz-Lara Iván Cavero-Redondo Vicente Martínez-Vizcaíno Vicente Martínez-Vizcaíno Maribel Lucerón-Lucas-Torres Carlos Pascual-Morena Irese Sequí-Domínguez |
| author_facet | Alicia Saz-Lara Iván Cavero-Redondo Vicente Martínez-Vizcaíno Vicente Martínez-Vizcaíno Maribel Lucerón-Lucas-Torres Carlos Pascual-Morena Irese Sequí-Domínguez |
| author_sort | Alicia Saz-Lara |
| collection | DOAJ |
| description | Background: Orthostatic hypotension, defined as a decrease in blood pressure on standing, is associated with an increased risk of mortality and cardiovascular events in the general population. In addition, it has recently been suggested that arterial stiffness is independently associated with orthostatic hypotension, which may be due to a loss of the buffering effect of the ascending aorta and an early return of pressure waves. However, the specific mechanisms underlying this association remain unclear. Thus, we aimed to evaluate the association between orthostatic hypotension and arterial stiffness in the adult population.Methods: PubMed, Scopus, Web of Science, and Cochrane Library databases were searched from inception to 31 January 2022. The DerSimonian and Laird method was used to calculate pooled odds ratio (OR) estimates and their respective 95% confidence intervals (95% CI) for the association between orthostatic hypotension and arterial stiffness.Results: Overall, 11 studies were included, with a total of 10,611 subjects. Our results showed that increased arterial stiffness raises the risk of orthostatic hypotension (OR: 1.40, 95% CI: 1.28–1.54), with a stronger association at central arterial stiffness (OR: 1.50, 95% CI: 1.34–1.68) than at peripheral arterial stiffness (OR: 1.29, 95% CI: 1.17–1.43).Conclusion: Our findings showed that increased arterial stiffness raises the risk of orthostatic hypotension by 40% among the adult population. Considering that orthostatic hypotension, which is usually a consequence of antihypertensive treatment, has been widely associated with the risk of cardiovascular events, appropriate control of arterial stiffness could be a clinical strategy to prevent cardiovascular morbidity and mortality. |
| first_indexed | 2024-04-09T13:18:32Z |
| format | Article |
| id | doaj.art-18d95e52998c4db0bb88a6fd20237f56 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-09T13:18:32Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-18d95e52998c4db0bb88a6fd20237f562023-05-11T11:17:49ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-04-011410.3389/fphys.2023.11645191164519Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysisAlicia Saz-Lara0Iván Cavero-Redondo1Vicente Martínez-Vizcaíno2Vicente Martínez-Vizcaíno3Maribel Lucerón-Lucas-Torres4Carlos Pascual-Morena5Irese Sequí-Domínguez6Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, SpainUniversidad Autónoma de Chile, Facultad de Ciencias de la Salud, Talca, ChileUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, SpainUniversidad Autónoma de Chile, Facultad de Ciencias de la Salud, Talca, ChileUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, SpainUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, SpainUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, SpainBackground: Orthostatic hypotension, defined as a decrease in blood pressure on standing, is associated with an increased risk of mortality and cardiovascular events in the general population. In addition, it has recently been suggested that arterial stiffness is independently associated with orthostatic hypotension, which may be due to a loss of the buffering effect of the ascending aorta and an early return of pressure waves. However, the specific mechanisms underlying this association remain unclear. Thus, we aimed to evaluate the association between orthostatic hypotension and arterial stiffness in the adult population.Methods: PubMed, Scopus, Web of Science, and Cochrane Library databases were searched from inception to 31 January 2022. The DerSimonian and Laird method was used to calculate pooled odds ratio (OR) estimates and their respective 95% confidence intervals (95% CI) for the association between orthostatic hypotension and arterial stiffness.Results: Overall, 11 studies were included, with a total of 10,611 subjects. Our results showed that increased arterial stiffness raises the risk of orthostatic hypotension (OR: 1.40, 95% CI: 1.28–1.54), with a stronger association at central arterial stiffness (OR: 1.50, 95% CI: 1.34–1.68) than at peripheral arterial stiffness (OR: 1.29, 95% CI: 1.17–1.43).Conclusion: Our findings showed that increased arterial stiffness raises the risk of orthostatic hypotension by 40% among the adult population. Considering that orthostatic hypotension, which is usually a consequence of antihypertensive treatment, has been widely associated with the risk of cardiovascular events, appropriate control of arterial stiffness could be a clinical strategy to prevent cardiovascular morbidity and mortality.https://www.frontiersin.org/articles/10.3389/fphys.2023.1164519/fullorthostatic hypotensionarterial stiffnesspulse wave velocityadultsmeta-analysis |
| spellingShingle | Alicia Saz-Lara Iván Cavero-Redondo Vicente Martínez-Vizcaíno Vicente Martínez-Vizcaíno Maribel Lucerón-Lucas-Torres Carlos Pascual-Morena Irese Sequí-Domínguez Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis Frontiers in Physiology orthostatic hypotension arterial stiffness pulse wave velocity adults meta-analysis |
| title | Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis |
| title_full | Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis |
| title_fullStr | Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis |
| title_full_unstemmed | Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis |
| title_short | Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis |
| title_sort | association between arterial stiffness and orthostatic hypotension a systematic review and meta analysis |
| topic | orthostatic hypotension arterial stiffness pulse wave velocity adults meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1164519/full |
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