Progress and Hurdles of Therapeutic Nanosystems against Cancer
Nanomedicine against cancer, including diagnosis, prevention and treatment, has increased expectations for the solution of many biomedical challenges in the fight against this disease. In recent decades, an exhaustive design of nanosystems with high specificity, sensitivity and selectivity has been...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/2/388 |
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| author | Marina Martín-Contreras Saúl A. Navarro-Marchal José Manuel Peula-García Ana Belén Jódar-Reyes |
| author_facet | Marina Martín-Contreras Saúl A. Navarro-Marchal José Manuel Peula-García Ana Belén Jódar-Reyes |
| author_sort | Marina Martín-Contreras |
| collection | DOAJ |
| description | Nanomedicine against cancer, including diagnosis, prevention and treatment, has increased expectations for the solution of many biomedical challenges in the fight against this disease. In recent decades, an exhaustive design of nanosystems with high specificity, sensitivity and selectivity has been achieved due to a rigorous control over their physicochemical properties and an understanding of the nano–bio interface. However, despite the considerable progress that has been reached in this field, there are still different hurdles that limit the clinical application of these nanosystems, which, along with their possible solutions, have been reviewed in this work. Specifically, physiological processes as biological barriers and protein corona formation related to the administration routes, designing strategies to overcome these obstacles, promising new multifunctional nanotherapeutics, and recent clinical trials are presented in this review. |
| first_indexed | 2024-03-09T21:13:40Z |
| format | Article |
| id | doaj.art-18da9ca597c54d6bbae075032b7d12e6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:13:40Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-18da9ca597c54d6bbae075032b7d12e62023-11-23T21:38:30ZengMDPI AGPharmaceutics1999-49232022-02-0114238810.3390/pharmaceutics14020388Progress and Hurdles of Therapeutic Nanosystems against CancerMarina Martín-Contreras0Saúl A. Navarro-Marchal1José Manuel Peula-García2Ana Belén Jódar-Reyes3Department of Applied Physics, University of Granada, Campus Fuentenueva s/n, 18071 Granada, SpainDepartment of Applied Physics, University of Granada, Campus Fuentenueva s/n, 18071 Granada, SpainDepartment of Applied Physics II, University of Málaga, 29016 Malaga, SpainDepartment of Applied Physics, University of Granada, Campus Fuentenueva s/n, 18071 Granada, SpainNanomedicine against cancer, including diagnosis, prevention and treatment, has increased expectations for the solution of many biomedical challenges in the fight against this disease. In recent decades, an exhaustive design of nanosystems with high specificity, sensitivity and selectivity has been achieved due to a rigorous control over their physicochemical properties and an understanding of the nano–bio interface. However, despite the considerable progress that has been reached in this field, there are still different hurdles that limit the clinical application of these nanosystems, which, along with their possible solutions, have been reviewed in this work. Specifically, physiological processes as biological barriers and protein corona formation related to the administration routes, designing strategies to overcome these obstacles, promising new multifunctional nanotherapeutics, and recent clinical trials are presented in this review.https://www.mdpi.com/1999-4923/14/2/388nanomedicinedesign of nanosystemsphysicochemical propertiesprotein coronatargetingdelivery |
| spellingShingle | Marina Martín-Contreras Saúl A. Navarro-Marchal José Manuel Peula-García Ana Belén Jódar-Reyes Progress and Hurdles of Therapeutic Nanosystems against Cancer Pharmaceutics nanomedicine design of nanosystems physicochemical properties protein corona targeting delivery |
| title | Progress and Hurdles of Therapeutic Nanosystems against Cancer |
| title_full | Progress and Hurdles of Therapeutic Nanosystems against Cancer |
| title_fullStr | Progress and Hurdles of Therapeutic Nanosystems against Cancer |
| title_full_unstemmed | Progress and Hurdles of Therapeutic Nanosystems against Cancer |
| title_short | Progress and Hurdles of Therapeutic Nanosystems against Cancer |
| title_sort | progress and hurdles of therapeutic nanosystems against cancer |
| topic | nanomedicine design of nanosystems physicochemical properties protein corona targeting delivery |
| url | https://www.mdpi.com/1999-4923/14/2/388 |
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