The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts

The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts

The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer drugs. However, the model is imperfect; animal models are ethically burdened, and the imperfect efficacy predictions contribute to high clin...

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Bibliographic Details
Main Authors: Job Komen, Sanne M. van Neerven, Elsbeth G. B. M. Bossink, Nina E. de Groot, Lisanne E. Nijman, Albert van den Berg, Louis Vermeulen, Andries D. van der Meer
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Micromachines
Subjects:
cancer-on-chip
xenograft
microfluidic
colorectal cancer
pharmacodynamics
pharmacokinetics
Online Access:https://www.mdpi.com/2072-666X/13/5/739

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