The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective
Background: In recent years, the involvement of the soluble urokinase Plasminogen Activator Receptor (suPAR) in the pathophysiological modulation of Rheumatoid Arthritis (RA) has been documented, resulting in the activation of several intracellular inflammatory pathways. Methods: We investigated the...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/12/1984 |
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| author | Maurizio Benucci Arianna Damiani Edda Russo Serena Guiducci Francesca Li Gobbi Paola Fusi Valentina Grossi Amedeo Amedei Mariangela Manfredi Maria Infantino |
| author_facet | Maurizio Benucci Arianna Damiani Edda Russo Serena Guiducci Francesca Li Gobbi Paola Fusi Valentina Grossi Amedeo Amedei Mariangela Manfredi Maria Infantino |
| author_sort | Maurizio Benucci |
| collection | DOAJ |
| description | Background: In recent years, the involvement of the soluble urokinase Plasminogen Activator Receptor (suPAR) in the pathophysiological modulation of Rheumatoid Arthritis (RA) has been documented, resulting in the activation of several intracellular inflammatory pathways. Methods: We investigated the correlation of urokinase Plasminogen Activator (uPA)/urokinase Plasminogen Activator Receptor (uPAR) expression and suPAR with inflammation and joint damage in RA, evaluating their potential role in a precision medicine context. Results: Currently, suPAR has been shown to be a potential biomarker for the monitoring of Systemic Chronic Inflammation (SCI) and COVID-19. However, the effects due to suPAR interaction in immune cells are also involved in both RA onset and progression. To date, the literature data on suPAR in RA endorse its potential application as a biomarker of inflammation and subsequent joint damage. Conclusion: Available evidence about suPAR utility in the RA field is promising, and future research should further investigate its use in clinical practice, resulting in a big step forward for precision medicine. As it is elevated in different types of inflammation, suPAR could potentially work as an adjunctive tool for the screening of RA patients. In addition, a suPAR system has been shown to be involved in RA pathogenesis, so new data about the therapeutic response to Jak inhibitors can represent a possible way to develop further studies. |
| first_indexed | 2024-03-09T16:12:37Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:12:37Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-18db4e9fe6d14425a21938dcbe4297ec2023-11-24T16:01:40ZengMDPI AGJournal of Personalized Medicine2075-44262022-12-011212198410.3390/jpm12121984The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine PerspectiveMaurizio Benucci0Arianna Damiani1Edda Russo2Serena Guiducci3Francesca Li Gobbi4Paola Fusi5Valentina Grossi6Amedeo Amedei7Mariangela Manfredi8Maria Infantino9Rheumatology Unit, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, 50143 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50134 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50134 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50134 Florence, ItalyRheumatology Unit, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, 50143 Florence, ItalyRheumatology Unit, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, 50143 Florence, ItalyImmunology and Allergology Laboratory, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, 50143 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50134 Florence, ItalyImmunology and Allergology Laboratory, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, 50143 Florence, ItalyImmunology and Allergology Laboratory, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, 50143 Florence, ItalyBackground: In recent years, the involvement of the soluble urokinase Plasminogen Activator Receptor (suPAR) in the pathophysiological modulation of Rheumatoid Arthritis (RA) has been documented, resulting in the activation of several intracellular inflammatory pathways. Methods: We investigated the correlation of urokinase Plasminogen Activator (uPA)/urokinase Plasminogen Activator Receptor (uPAR) expression and suPAR with inflammation and joint damage in RA, evaluating their potential role in a precision medicine context. Results: Currently, suPAR has been shown to be a potential biomarker for the monitoring of Systemic Chronic Inflammation (SCI) and COVID-19. However, the effects due to suPAR interaction in immune cells are also involved in both RA onset and progression. To date, the literature data on suPAR in RA endorse its potential application as a biomarker of inflammation and subsequent joint damage. Conclusion: Available evidence about suPAR utility in the RA field is promising, and future research should further investigate its use in clinical practice, resulting in a big step forward for precision medicine. As it is elevated in different types of inflammation, suPAR could potentially work as an adjunctive tool for the screening of RA patients. In addition, a suPAR system has been shown to be involved in RA pathogenesis, so new data about the therapeutic response to Jak inhibitors can represent a possible way to develop further studies.https://www.mdpi.com/2075-4426/12/12/1984suPARuPA/uPARrheumatoid arthritisdisease activity scoresystemic chronic inflammation |
| spellingShingle | Maurizio Benucci Arianna Damiani Edda Russo Serena Guiducci Francesca Li Gobbi Paola Fusi Valentina Grossi Amedeo Amedei Mariangela Manfredi Maria Infantino The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective Journal of Personalized Medicine suPAR uPA/uPAR rheumatoid arthritis disease activity score systemic chronic inflammation |
| title | The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective |
| title_full | The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective |
| title_fullStr | The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective |
| title_full_unstemmed | The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective |
| title_short | The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective |
| title_sort | association of upa upar and supar system with inflammation and joint damage in rheumatoid arthritis supar as a biomarker in the light of a personalized medicine perspective |
| topic | suPAR uPA/uPAR rheumatoid arthritis disease activity score systemic chronic inflammation |
| url | https://www.mdpi.com/2075-4426/12/12/1984 |
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