Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

Histone deacetylase (HDAC) inhibitors have promising neuroprotective and anti-inflammatory properties although the exact mechanisms are unclear. We have earlier showed that factors from lipopolysaccharide (LPS)-activated microglia can down-regulate the astroglial nuclear factor-erythroid 2-related f...

Full description

Bibliographic Details
Main Authors: Fernando Correa, Carina Mallard, Michael Nilsson, Mats Sandberg
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Neurobiology of Disease
Subjects:
Neuroinflammation
Nrf2
Valproic acid
Trichostatin-A
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002233

Similar Items

Similar Items