Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs
Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoea (5–7%) are the most common side effects. The aim...
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MDPI AG
2021-06-01
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| author | Jan Bures Ilja Tacheci Jaroslav Kvetina Vera Radochova Darina Kohoutova Martin Valis Stanislav Rejchrt Veronika Knoblochova Jana Zdarova Karasova |
| author_facet | Jan Bures Ilja Tacheci Jaroslav Kvetina Vera Radochova Darina Kohoutova Martin Valis Stanislav Rejchrt Veronika Knoblochova Jana Zdarova Karasova |
| author_sort | Jan Bures |
| collection | DOAJ |
| description | Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoea (5–7%) are the most common side effects. The aim of this study was to assess the effect of galantamine on porcine gastric myoelectric activity without (Group A) and with (Group B) dextran sodium sulphate (DSS)-induced gastrointestinal injury. Galantamine hydrobromide was administrated to twelve pigs as a single intragastric dose (24 mg). Gastric myoelectric activity was investigated by electrogastrography (EGG). Basal (15 min before galantamine administration) and study recordings after galantamine administration (300 min) were evaluated using a running spectral analysis. Results were expressed as dominant frequency of gastric slow waves and power analysis (areas of amplitudes). Altogether, 3780 one-minute EGG recordings were evaluated. In Group A, power was steady from basal values for 180 min, then gradually decreased till 270 min (<i>p</i> = 0.007). In Group B, there was a rapid gradual fall from basal values to those after 120 min (<i>p</i> = 0.007) till 300 min (<i>p</i> ˂ 0.001). In conclusion, galantamine alone revealed an unfavourable effect on porcine myoelectric activity assessed by gastric power. It can be a plausible explanation of galantamine-associated dyspepsia in humans. DSS caused further profound decrease of EGG power. That may indicate that underlying inflammatory, ischaemic or NSAIDs-induced condition of the intestine in humans can have aggravated the effect of galantamine on gastric myoelectric activity. |
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| language | English |
| last_indexed | 2024-03-10T10:16:15Z |
| publishDate | 2021-06-01 |
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| series | Pharmaceuticals |
| spelling | doaj.art-18dd72615a184ffbb613d098ea3a205c2023-11-22T00:46:26ZengMDPI AGPharmaceuticals1424-82472021-06-0114659010.3390/ph14060590Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental PigsJan Bures0Ilja Tacheci1Jaroslav Kvetina2Vera Radochova3Darina Kohoutova4Martin Valis5Stanislav Rejchrt6Veronika Knoblochova7Jana Zdarova Karasova82nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, 500 03 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, 500 03 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, 500 03 Hradec Kralove, Czech RepublicAnimal Laboratory, Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, 500 03 Hradec Kralove, Czech RepublicDepartment of Neurology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, 500 03 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, 500 03 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, 500 03 Hradec Kralove, Czech RepublicDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech RepublicGalantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoea (5–7%) are the most common side effects. The aim of this study was to assess the effect of galantamine on porcine gastric myoelectric activity without (Group A) and with (Group B) dextran sodium sulphate (DSS)-induced gastrointestinal injury. Galantamine hydrobromide was administrated to twelve pigs as a single intragastric dose (24 mg). Gastric myoelectric activity was investigated by electrogastrography (EGG). Basal (15 min before galantamine administration) and study recordings after galantamine administration (300 min) were evaluated using a running spectral analysis. Results were expressed as dominant frequency of gastric slow waves and power analysis (areas of amplitudes). Altogether, 3780 one-minute EGG recordings were evaluated. In Group A, power was steady from basal values for 180 min, then gradually decreased till 270 min (<i>p</i> = 0.007). In Group B, there was a rapid gradual fall from basal values to those after 120 min (<i>p</i> = 0.007) till 300 min (<i>p</i> ˂ 0.001). In conclusion, galantamine alone revealed an unfavourable effect on porcine myoelectric activity assessed by gastric power. It can be a plausible explanation of galantamine-associated dyspepsia in humans. DSS caused further profound decrease of EGG power. That may indicate that underlying inflammatory, ischaemic or NSAIDs-induced condition of the intestine in humans can have aggravated the effect of galantamine on gastric myoelectric activity.https://www.mdpi.com/1424-8247/14/6/590Alzheimer diseasegalantamineelectrogastrographyexperimental pigsgastric motor dysmotilitysmall bowel transit time |
| spellingShingle | Jan Bures Ilja Tacheci Jaroslav Kvetina Vera Radochova Darina Kohoutova Martin Valis Stanislav Rejchrt Veronika Knoblochova Jana Zdarova Karasova Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs Pharmaceuticals Alzheimer disease galantamine electrogastrography experimental pigs gastric motor dysmotility small bowel transit time |
| title | Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs |
| title_full | Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs |
| title_fullStr | Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs |
| title_full_unstemmed | Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs |
| title_short | Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs |
| title_sort | dextran sodium sulphate induced gastrointestinal injury further aggravates the impact of galantamine on the gastric myoelectric activity in experimental pigs |
| topic | Alzheimer disease galantamine electrogastrography experimental pigs gastric motor dysmotility small bowel transit time |
| url | https://www.mdpi.com/1424-8247/14/6/590 |
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